Vortioxetine - Revision history

Zeki at 06:21, 8 August 2024

2024-08-08T06:21:13Z

← Older revision		Revision as of 02:21, 8 August 2024
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	\| Withdrawal Symptoms: If the medication is abruptly stopped, symptoms may include anxiety, irritability, mood swings, restlessness, changes in sleep habits, headache, sweating, shaking, nausea, dizziness, and electric shock-like sensations.		\| Withdrawal Symptoms: If the medication is abruptly stopped, symptoms may include anxiety, irritability, mood swings, restlessness, changes in sleep habits, headache, sweating, shaking, nausea, dizziness, and electric shock-like sensations.
	\|}		\|}

			==Pharmacokinetics==
			*Metabolism: Primarily via CYP2D6
			*Elimination: Half-life approximately 66 hours
			*Onset: 2 - 4 weeks for full antidepressant effect

			==Drug Precautions==
			'''Pregnancy

			Use only if potential benefit outweighs risk. May cause withdrawal symptoms in newborns if used in third trimester.

			'''Breastfeeding

			Use caution

			'''Children and Elderly
			*Not approved for use in children <18 years
			*No dosage adjustment required for elderly patients

			'''Monitoring Requirements
			*Monitor for clinical worsening and suicidal thoughts, especially early in treatment
			*Monitor for signs of serotonin syndrome
			*Monitor for signs of abnormal bleeding

			'''Drug Interactions
			*Strong CYP2D6 inhibitors: Reduce vortioxetine dose by half
			*Strong CYP inducers: Consider dose increase
			*Anticoagulants: Monitor for increased bleeding risk

			==FAQ==
			'''How Should I Take the Tablet?

			Take once daily with or without food

			'''What Should I Avoid While Taking?

			Avoid alcohol. Use caution when driving or operating machinery until you know how it affects you.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not double doses.

Zeki: /* Side Effects */

2024-08-08T06:06:30Z

Side Effects

← Older revision		Revision as of 02:06, 8 August 2024
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	\|-		\|-
	\| rowspan="7" \| '''Common		\| rowspan="7" \| '''Common
	\|-
	\| Nausea: This is the most frequently reported side effect, occurring in up to 42% of patients		\| Nausea: This is the most frequently reported side effect, occurring in up to 42% of patients
	\|-		\|-

Zeki at 06:03, 8 August 2024

2024-08-08T06:03:38Z

← Older revision		Revision as of 02:03, 8 August 2024
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	*5-HT<sub>1B</sub> receptor partial agonist		*5-HT<sub>1B</sub> receptor partial agonist
	*5-HT<sub>3</sub>, 5-HT<sub>1D</sub> and 5-HT<sub>7</sub> receptor antagonist		*5-HT<sub>3</sub>, 5-HT<sub>1D</sub> and 5-HT<sub>7</sub> receptor antagonist

			==Route of Administration==
			Oral

			==Dosages==
			*Starting dose: 10 mg once daily
			*Maintenance dose: 5 - 20 mg once daily
			*Maximum dose: 20 mg/day

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="7" \| '''Common
			\|-
			\| Nausea: This is the most frequently reported side effect, occurring in up to 42% of patients
			\|-
			\| Constipation or diarrhoea: Reported in up to 15% of patients
			\|-
			\| Vomiting
			\|-
			\| Dry Mouth: Using sugar-free gum or candy can help alleviate dry mouth
			\|-
			\| Dizziness: Moving slowly when changing positions can help reduce dizziness
			\|-
			\| Headache: Drinking plenty of fluids and resting can help; avoid excessive alcohol consumption
			\|-
			\| Sexual Dysfunction: This includes decreased libido and difficulty achieving orgasm
			\|-
			\| rowspan="9" \| '''Serious
			\| '''Serious side effects are less common but require immediate medical attention. '''
			\|-
			\| Suicidal Thoughts or Actions: especially in the first few months of treatment or when the dose is changed. Symptoms include new or worsening depression, anxiety, or unusual changes in mood or behavior.
			\|-
			\| Serotonin Syndrome: This potentially life-threatening condition can occur when there is too much serotonin in the body. Symptoms include agitation, hallucinations, rapid heart rate, fever, nausea, vomiting, diarrhea, and muscle twitching
			\|-
			\| Severe Allergic Reactions: These include symptoms like difficulty breathing, swelling of the face, lips, tongue, or throat, and severe rash or hives
			\|-
			\| Abnormal Bleeding: Can manifest as unusual bruising or bleeding
			\|-
			\| Low Sodium Levels: Particularly in older adults, symptoms include headache, confusion, weakness, and difficulty concentrating
			\|-
			\| Mania: Symptoms include excessively high energy, severe trouble sleeping, racing thoughts, reckless behavior, and unusually grand ideas
			\|-
			\| Angle-closure glaucoma (eye pain, vision changes)
			\|-
			\| Withdrawal Symptoms: If the medication is abruptly stopped, symptoms may include anxiety, irritability, mood swings, restlessness, changes in sleep habits, headache, sweating, shaking, nausea, dizziness, and electric shock-like sensations.
			\|}

Zeki: /* Mechanism of Action */

2024-08-08T05:29:08Z

Mechanism of Action

← Older revision		Revision as of 01:29, 8 August 2024
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	*5-HT<sub>1A</sub> receptor agonist		*5-HT<sub>1A</sub> receptor agonist
	*5-HT<sub>1B</sub> receptor partial agonist		*5-HT<sub>1B</sub> receptor partial agonist
	*5-HT<sub>3</sub>, 5-HT<sub>1D</sub> and 5-HT<~~sbu~~>7</sub> receptor antagonist		*5-HT<sub>3</sub>, 5-HT<sub>1D</sub> and 5-HT<sub>7</sub> receptor antagonist

Zeki at 05:28, 8 August 2024

2024-08-08T05:28:56Z

← Older revision		Revision as of 01:28, 8 August 2024
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	'''Vortioxetine (BRINTELLIX)'''（中文：[[沃替西汀]]）		'''Vortioxetine (BRINTELLIX)'''（中文：[[沃替西汀]]）
			==Common Strengths of Vortioxetine==
			Vortioxetine are available in the following strengths:
			*5 mg, 10 mg, 20 mg tablets

			==Drug Trade Names of Vortioxetine==
			Brintellix

			==Drug Usage==
			Treatment of major depressive disorder in adults

			==Mechanism of Action==
			Vortioxetine has a miltimodal mechanism of action:
			*Serotonin reuptake inhibitor
			*5-HT<sub>1A</sub> receptor agonist
			*5-HT<sub>1B</sub> receptor partial agonist
			*5-HT<sub>3</sub>, 5-HT<sub>1D</sub> and 5-HT<sbu>7</sub> receptor antagonist

Zeki: Created page with "Category: DrugsCategory: Selective serotonin reuptake inhibitor '''Antidepressant Drug''' '''Drug class: :Category: Selective..."

2024-08-08T04:01:05Z

Created page with "Category: Drugs Category: Selective serotonin reuptake inhibitor '''Antidepressant Drug''' '''Drug class: :Category: Selective..."

New page

[[Category: Drugs]][[Category: Selective serotonin reuptake inhibitor]]

[[:Category: Antidepressant Drug | '''Antidepressant Drug''']]

'''Drug class: [[:Category: Selective serotonin reuptake inhibitor | Selective Serotonin Reuptake Inhibitor]]

'''Vortioxetine (BRINTELLIX)'''（中文：[[沃替西汀]]）