Dexlansoprazole (DEXILANT): Difference between revisions
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==Drug Class== | ==Drug Class== | ||
Proton Pump Inhibitors (PPI) | Proton Pump Inhibitors (PPI) | ||
==Common Strengths of Dexlansoprazole capsule== | |||
Dexlansoprazole capsule are available in the following strengths: | |||
*30 mg delayed-release capsules | |||
*60mg delayed-release capsules | |||
==Drug Trade Names of Dexlansoprazole capsule== | |||
Dexilant | |||
==Drug Usage== | |||
Dexlansoprazole is used for: | |||
*Healing of erosive esophagitis (EE) | |||
*Maintenance of healed erosive esophagitis (EE) | |||
*Treatment of gastroesophageal reflux disease (GERD) | |||
==Mechanism of Action== | |||
Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking gastric acid production in the stomach | |||
==Route of Administration== | |||
Oral | |||
==Dosages == | |||
For adults and children aged 12 years and older, the typical dosage is: | |||
Healing: 60 mg once daily for up to 8 weeks | |||
Maintenance: 30 mg once daily for up to 6 months | |||
GERD: 30 mg once daily for up to 4 weeks | |||
==Renal Dose Adjustments== | |||
No renal dose adjustment recommended | |||
==Side Effects== | |||
{| class="wikitable" | |||
!style="text-align: left"| Frequency | |||
!Adverse reactions | |||
|- | |||
| rowspan=6 | '''Common Side Effects | |||
|- | |||
| Diarrhea | |||
|- | |||
| Abdominal pain | |||
|- | |||
| Nausea | |||
|- | |||
| Vomiting | |||
|- | |||
| Flatulence | |||
|- | |||
| rowspan=6 | '''Serious Side Effects | |||
|- | |||
| Bone fractures | |||
|- | |||
| Low blood magnesium levels | |||
|- | |||
| Clostridium difficile infection | |||
|- | |||
| Anaphylaxis | |||
|- | |||
| Vitamin B12 deficiency | |||
|} | |||
==Pharmacokinetics== | |||
Dual-release mechanism | |||
Onset of action: 1-2 hours (first peak), 4-5 hours (second peak); | |||
Duration of action: Up to 24 hours, longer than other PPIs | |||
==Drug Precautions== | |||
Pregnancy: Caution advised; Children: Safety not established; Elderly: Monitoring recommended | |||
Breastfeeding: safety during breastfeeding is unclear | |||
Children and Elderly: Approved for use in children aged 12 years and older; elderly patients may require monitoring due to potential increased sensitivity. | |||
==Monitoring Items== | |||
Regular monitoring of magnesium and vitamin B12 levels | |||
==Drug Interactions== | |||
Dexlansoprazole can interact with drugs metabolized by CYP2C19 and CYP3A4 enzymes | |||
Interacts with methotrexate, digoxin, warfarin, certain antiretrovirals | |||
==FAQ== | |||
'''How should I take the tablet? | |||
Take with or without food; swallow whole or sprinkle on apple sauce/water | |||
'''What should I avoid while taking? | |||
Avoid highly acidic foods and grapefruit | |||
'''What happens if I miss a dose? | |||
Take as soon as remembered unless close to next dose; do not double up on doses | |||
Revision as of 02:34, 6 January 2025
Drug class: Proton Pump Inhibitors (PPI)
Dexlansoprazole (中文: 右蘭索拉唑)
Drug Class
Proton Pump Inhibitors (PPI)
Common Strengths of Dexlansoprazole capsule
Dexlansoprazole capsule are available in the following strengths:
- 30 mg delayed-release capsules
- 60mg delayed-release capsules
Drug Trade Names of Dexlansoprazole capsule
Dexilant
Drug Usage
Dexlansoprazole is used for:
- Healing of erosive esophagitis (EE)
- Maintenance of healed erosive esophagitis (EE)
- Treatment of gastroesophageal reflux disease (GERD)
Mechanism of Action
Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking gastric acid production in the stomach
Route of Administration
Oral
Dosages
For adults and children aged 12 years and older, the typical dosage is:
Healing: 60 mg once daily for up to 8 weeks
Maintenance: 30 mg once daily for up to 6 months
GERD: 30 mg once daily for up to 4 weeks
Renal Dose Adjustments
No renal dose adjustment recommended
Side Effects
| Frequency | Adverse reactions |
|---|---|
| Common Side Effects | |
| Diarrhea | |
| Abdominal pain | |
| Nausea | |
| Vomiting | |
| Flatulence | |
| Serious Side Effects | |
| Bone fractures | |
| Low blood magnesium levels | |
| Clostridium difficile infection | |
| Anaphylaxis | |
| Vitamin B12 deficiency |
Pharmacokinetics
Dual-release mechanism
Onset of action: 1-2 hours (first peak), 4-5 hours (second peak);
Duration of action: Up to 24 hours, longer than other PPIs
Drug Precautions
Pregnancy: Caution advised; Children: Safety not established; Elderly: Monitoring recommended
Breastfeeding: safety during breastfeeding is unclear
Children and Elderly: Approved for use in children aged 12 years and older; elderly patients may require monitoring due to potential increased sensitivity.
Monitoring Items
Regular monitoring of magnesium and vitamin B12 levels
Drug Interactions
Dexlansoprazole can interact with drugs metabolized by CYP2C19 and CYP3A4 enzymes
Interacts with methotrexate, digoxin, warfarin, certain antiretrovirals
FAQ
How should I take the tablet?
Take with or without food; swallow whole or sprinkle on apple sauce/water
What should I avoid while taking?
Avoid highly acidic foods and grapefruit
What happens if I miss a dose?
Take as soon as remembered unless close to next dose; do not double up on doses
