Dexlansoprazole (DEXILANT): Difference between revisions
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[[Category: Drugs]][[Category: Proton Pump Inhibitors (PPI)]][[:Category: Gastrointestinal | [[Category: Drugs]][[Category: Proton Pump Inhibitors (PPI)]][[:Category: Gastrointestinal Drug | '''Gastrointestinal Drug''']] | ||
'''Drug class: [[:Category: Proton Pump Inhibitors (PPI) | Proton Pump Inhibitors (PPI)]]''' | '''Drug class: [[:Category: Proton Pump Inhibitors (PPI) | Proton Pump Inhibitors (PPI)]]''' | ||
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==Drug Class== | ==Drug Class== | ||
Proton Pump | Proton Pump Inhibitors (PPI) | ||
==Common Strengths== | ==Common Strengths of Dexlansoprazole capsule== | ||
Dexlansoprazole capsule are available in the following strengths: | |||
*30 mg delayed-release capsules | *30 mg delayed-release capsules | ||
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*60mg delayed-release capsules | *60mg delayed-release capsules | ||
==Drug Trade | ==Drug Trade Names of Dexlansoprazole capsule== | ||
Dexilant | Dexilant | ||
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==Drug Usage== | ==Drug Usage== | ||
Healing of erosive esophagitis (EE) | Dexlansoprazole is used for: | ||
*Healing of erosive esophagitis (EE) | |||
Maintenance of healed erosive esophagitis (EE) | *Maintenance of healed erosive esophagitis (EE) | ||
Treatment of gastroesophageal reflux disease (GERD) | *Treatment of gastroesophageal reflux disease (GERD) | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
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No renal dose adjustment recommended | No renal dose adjustment recommended | ||
== | ==Side Effects== | ||
{| class="wikitable" | |||
!style="text-align: left"| Frequency | |||
!Adverse reactions | |||
|- | |||
| rowspan=6 | '''Common Side Effects | |||
|- | |||
| Diarrhea | |||
|- | |||
| Abdominal pain | |||
|- | |||
| Nausea | |||
|- | |||
| Vomiting | |||
|- | |||
| Flatulence | |||
|- | |||
| rowspan=6 | '''Serious Side Effects | |||
|- | |||
| Bone fractures | |||
|- | |||
| Low blood magnesium levels | |||
|- | |||
| Clostridium difficile infection | |||
|- | |||
| Anaphylaxis | |||
|- | |||
| Vitamin B12 deficiency | |||
|} | |||
==Pharmacokinetics== | ==Pharmacokinetics== | ||
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==FAQ== | ==FAQ== | ||
'''How should I take the tablet? | |||
Take with or without food; swallow whole or sprinkle on apple sauce/water | Take with or without food; swallow whole or sprinkle on apple sauce/water | ||
'''What should I avoid while taking? | |||
Avoid highly acidic foods and grapefruit | Avoid highly acidic foods and grapefruit | ||
'''What happens if I miss a dose? | |||
Take as soon as remembered unless close to next dose; do not double up on doses | Take as soon as remembered unless close to next dose; do not double up on doses | ||
Latest revision as of 02:48, 6 January 2025
Drug class: Proton Pump Inhibitors (PPI)
Dexlansoprazole (中文: 右蘭索拉唑)
Drug Class[edit]
Proton Pump Inhibitors (PPI)
Common Strengths of Dexlansoprazole capsule[edit]
Dexlansoprazole capsule are available in the following strengths:
- 30 mg delayed-release capsules
- 60mg delayed-release capsules
Drug Trade Names of Dexlansoprazole capsule[edit]
Dexilant
Drug Usage[edit]
Dexlansoprazole is used for:
- Healing of erosive esophagitis (EE)
- Maintenance of healed erosive esophagitis (EE)
- Treatment of gastroesophageal reflux disease (GERD)
Mechanism of Action[edit]
Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking gastric acid production in the stomach
Route of Administration[edit]
Oral
Dosages[edit]
For adults and children aged 12 years and older, the typical dosage is:
Healing: 60 mg once daily for up to 8 weeks
Maintenance: 30 mg once daily for up to 6 months
GERD: 30 mg once daily for up to 4 weeks
Renal Dose Adjustments[edit]
No renal dose adjustment recommended
Side Effects[edit]
| Frequency | Adverse reactions |
|---|---|
| Common Side Effects | |
| Diarrhea | |
| Abdominal pain | |
| Nausea | |
| Vomiting | |
| Flatulence | |
| Serious Side Effects | |
| Bone fractures | |
| Low blood magnesium levels | |
| Clostridium difficile infection | |
| Anaphylaxis | |
| Vitamin B12 deficiency |
Pharmacokinetics[edit]
Dual-release mechanism
Onset of action: 1-2 hours (first peak), 4-5 hours (second peak);
Duration of action: Up to 24 hours, longer than other PPIs
Drug Precautions[edit]
Pregnancy: Caution advised; Children: Safety not established; Elderly: Monitoring recommended
Breastfeeding: safety during breastfeeding is unclear
Children and Elderly: Approved for use in children aged 12 years and older; elderly patients may require monitoring due to potential increased sensitivity.
Monitoring Items[edit]
Regular monitoring of magnesium and vitamin B12 levels
Drug Interactions[edit]
Dexlansoprazole can interact with drugs metabolized by CYP2C19 and CYP3A4 enzymes
Interacts with methotrexate, digoxin, warfarin, certain antiretrovirals
FAQ[edit]
How should I take the tablet?
Take with or without food; swallow whole or sprinkle on apple sauce/water
What should I avoid while taking?
Avoid highly acidic foods and grapefruit
What happens if I miss a dose?
Take as soon as remembered unless close to next dose; do not double up on doses
