Pregabalin: Difference between revisions

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'''Epilepsy,  
'''Epilepsy,  
 
{|class="wikitable"
''By mouth'': the initial oral dose is 25 mg twice daily, increased at weekly intervals in steps of 50 mg daily to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to max. 600 mg daily in 2-3 divided doses.
!style="text-align: left"|By mouth
|the initial oral dose is 25 mg twice daily, increased at weekly intervals in steps of 50 mg daily to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to max. 600 mg daily in 2-3 divided doses.
|}


'''Neuropathic Pain
'''Neuropathic Pain


{|class="wikitable"
{|class="wikitable"
!style="text-align: left"| {|class="wikitable"
!style="text-align: left"|By mouth
!style="text-align: left"| Oral bioavailability
|initially 150 mg daily in 2-3 divided doses, increased if necessary after 3-7 days to
|Gabapentin is absorbed from the intestines by means of an active transport process which is saturable, so the pharmacokinetics of gabapentin are dose-dependent, with diminished bioavailability and delayed peak levels at higher doses.
                  300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to
Food increases the bioavailability by about 10%.
                  Max. 600 mg daily in 2-3 divided doses.
|-
!style="text-align: left"| Onset of action
|Gabapentin at a low dose of 100 mg has a Tmax  (time to peak levels) of about 1.7 hours, while the Tmax increases to 3 to 4 hours at higher doses.
|-
!style="text-align: left"| Metabolism
|Gabapentin undergoes little or no metabolism.
|-
!style="text-align: left"| Elimination half-life
|Gabapentin is eliminated renally in the urine.
The elimination half-life has been reported to be about 5 to 7 hours. Gabapentin is distributed into breast milk.
 
|}
 
|Gabapentin is absorbed from the intestines by means of an active transport process which is saturable, so the pharmacokinetics of gabapentin are dose-dependent, with diminished bioavailability and delayed peak levels at higher doses.
Food increases the bioavailability by about 10%.
|-
!style="text-align: left"| Onset of action
|Gabapentin at a low dose of 100 mg has a Tmax  (time to peak levels) of about 1.7 hours, while the Tmax increases to 3 to 4 hours at higher doses.
|-
!style="text-align: left"| Metabolism
|Gabapentin undergoes little or no metabolism.  
|-
!style="text-align: left"| Elimination half-life
|Gabapentin is eliminated renally in the urine.
The elimination half-life has been reported to be about 5 to 7 hours. Gabapentin is distributed into breast milk.  


|}
|}

Revision as of 21:46, 5 October 2020

Pronunciation

Pregabalin 150mg

Pregabalin 25mg

Pregabalin 50mg


Introduction

Gabapentin is an anticonvulsant medication:

  • Peripheral and central neuropathic pain
  • Used as an adjunctive therapy for focal seizures with or without secondary generalization.
  • Generalized anxiety disorder


Mechanism of Action

Anticonvulsant medication. It inhibits the alpha 2-delta subunit of voltage-dependent calcium channels.


Generic Name 藥名 HA Code 藥物代碼 Classification藥物分類
Pregabalin Capsule 25mg PREG15 P1S1S3


Dosage

Epilepsy,

By mouth the initial oral dose is 25 mg twice daily, increased at weekly intervals in steps of 50 mg daily to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to max. 600 mg daily in 2-3 divided doses.

Neuropathic Pain

By mouth initially 150 mg daily in 2-3 divided doses, increased if necessary after 3-7 days to 
                  300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to  
                 Max. 600 mg daily in 2-3 divided doses.
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