Perindopril

Pronunciation

Perindopril 4mg (ACERTIL 4mg)

Generic Name:	Perindopril
Class:	Cardiovascular Drug
Subclass:	ACE inhibitor
Legal Classification:	P1S1S3

Drug Names

Generic Name 藥物化學名稱	HA Code 藥物代碼	Legal Classification法律藥物分類	Brand Name 品牌名稱
Perindopril Tertbutylamine Tab 2mg	PERI28	P1S1S3	ACERTIL AR Tablet 5mg
Perindopril Tertbutylamine Tab 4mg	PERI17	P1S1S3	ACERTIL AR Tablet 10mg
Perindopril Arginine Tab 5mg	PERI29	P1S1S	ACERTIL PLUS TAB 2.5mg/0.625mg (perindopril arginine 5 mg, indapamide 0.625mg)
Perindopril Arginine Tab 10mg			ACERTIL PLUS TAB 5MG/1.25MG (perindopril arginine 5 mg, indapamide 1.25mg)
			ACERTIL PLUS TAB 10mg/2.5mg (perindopril arginine 10 mg, indapamide 2.5mg)

Mechanism of Action

Perindopril is an inhibitor of angiotensin-I converting enzyme (ACE inhibitor). The beneficial effects of ACE inhibitors appear to result primarily from the suppression of the plasma renin-angiotensin-aldosterone system. Renin is synthesized by the kidneys and released into the circulation where it converts angiotensinogen to angiotensin-I. Angiotensin-I is then converted by angiotensin converting enzyme to angiotensin-II. Angiotensin-II is a potent vasoconstrictor responsible for arterial vasoconstriction and increased blood pressure, as well as for stimulation of the adrenal gland to secrete aldosterone. Inhibition of ACE results in decreased plasma angiotensin-II, which leads to decreased vasopressor activity and to reduced aldosterone secretion. The latter decrease may result in an increase in serum potassium concentration. Perindopril is used in the treatment of hypertension and heart failure. Perindopril helps to reduce the risk of future strokes and heart attacks. It also improves your survival if you are taking it following a heart attack or heart surgery. It works by widening your blood vessels and making it easier for your heart to pump blood around your body. This can improve the symptoms of heart failure.

Perindopril can be used alone or in combination with other antihypertensive agent such as indapamide.

Route of Administration

Perindopril is administered orally in a single daily dose

Dosage

Dose for perindopril Tertbutylamine

• Hypertension - 4mg once a day (the maximum dose is 8 mg once daily)
• Heart failure – 4mg once a day
• After a heart attack – 8mg once a day

Dose for perindopril Arginine

• Hypertension - 5mg once a day (the maximum dose is 10 mg once daily)
• Heart failure – 5mg once a day
• After a heart attack – 10mg once a day

When will I feel better?

Perindopril starts to work within a few hours to reduce high blood pressure, but it may take up to a month to achieve its full effect.

If you are taking perindopril for heart failure, it may take weeks, even months, before you feel better.