Sertraline

Antidepressant Drug

Drug class: Selective Serotonin Reuptake Inhibitor

Sertraline (ZOLOFT)（中文：舍曲林）

Common Strengths of Sertraline

Sertraline are available in the following strengths:

• Tablets: 25 mg, 50 mg, 100 mg
• Capsules: 150 mg, 200 mg
• Oral solution: 20 mg/mL

Drug Trade Names of Sertraline

Zoloft

Drug Usage

• Major depressive disorder
• Obsessive-compulsive disorder (OCD)
• Panic disorder
• Social anxiety disorder
• Generalized anxiety disorder
• Post-traumatic stree disorder (PTSD)

Mechanism of Action

Sertraline is a selective serotonin reuptake inhibitor (SSRI). It works by increaasing serotonin levels in the brain by inhibiting its reuptake into presynaptic neurons, thereby enhancing serotonergic activity.

Route of Administration

Oral

Dosages

• Depression: 50 mg/day initially, may increase to 200 mg/day maximum
• Obsessive-compulsive disorder (OCD): 50 mg/day initially, may increase to 200 mg/day maximum
• Panic disorder: 25 mg/day initially, may increase to 200 mg/day maximum

Renal dose based on eGFR:

• For severe renal impairment (eGFR <30 mL/min): 25 mg/day initially, may titrate up to 200 mg/day maximum

Side Effects

Frequency	Adverse reactions
Common	Nausea: Often mitiagated by taking the medication with food
	Headaches: Drinking plenty of fluids and resting can help; avoid excessive alcohol consumption
	Insomnia: Taking fluoxetine in the morming may reduce sleep disurbances
	Fatigue or Weakness: Resting and avoiding activities that require alertness, such as driving
	Sexual Dysfunction: This includes decreased libido and difficulty achieving orgasm
	Diarrhoea
	Dry Mouth: Staying hydrated and using sugar-free gum or candy can help alleviate dry mouth
	Dizziness: Moving slowly when changing positions can help reduce dizziness
	Sweating
	Anxiety
	Tremor/shaking
	Indigestion/heratburn
Serious	Suicidal Thoughts or Actions: Especially in the first few months of treatment or when the dose is changed. Symptoms include new or worsening depression, anxiety, or unusua changes in mood or behavior.