Trazodone: Difference between revisions
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Trazodone are available in the following strengths: | Trazodone are available in the following strengths: | ||
*50 mg, 75 mg, 100 mg, 150 mg | *50 mg, 75 mg, 100 mg, 150 mg | ||
==Drug Trade Names of Trazodone== | |||
*Trittico | |||
*Desyrel | |||
==Drug Usage== | |||
*Major depressive disorder (MDD) | |||
*Off-label uses: Anxiety, insomnia, alcohol dependence | |||
==Mechanism of Action== | |||
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). It works by: | |||
*Antagonizing 5-HT<sub>2A</sub> receptors | |||
*Inhibiting serotonin reuptake | |||
*Blocking histamine H1 and α1-adrenergic receptors | |||
==Route of Administration== | |||
Oral | |||
==Dosages== | |||
*Major depressive disorder (MDD): | |||
**Initial: 150 mg/day in divided doses | |||
**Maintenance: 150-400 mg/day | |||
**Maximum: 400 mg/day (outpatients), 600 mg/day (inpatients) | |||
Trazodone can be used in patients with renal impairment without specific adjustments, careful monitoring and cautious titration are advised to ensure safety and efficacy. | |||
Revision as of 04:11, 12 August 2024
Drug class: Atypical Antidepressants
Trazodone (TRITTICO)（中文：曲唑酮）
Pronunciation
Trazodone 50mg
Common Strengths of Trazodone
Trazodone are available in the following strengths:
- 50 mg, 75 mg, 100 mg, 150 mg
Drug Trade Names of Trazodone
- Trittico
- Desyrel
Drug Usage
- Major depressive disorder (MDD)
- Off-label uses: Anxiety, insomnia, alcohol dependence
Mechanism of Action
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). It works by:
- Antagonizing 5-HT2A receptors
- Inhibiting serotonin reuptake
- Blocking histamine H1 and α1-adrenergic receptors
Route of Administration
Oral
Dosages
- Major depressive disorder (MDD):
- Initial: 150 mg/day in divided doses
- Maintenance: 150-400 mg/day
- Maximum: 400 mg/day (outpatients), 600 mg/day (inpatients)
Trazodone can be used in patients with renal impairment without specific adjustments, careful monitoring and cautious titration are advised to ensure safety and efficacy.
