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| ==Drug Class== | | ==Drug Class== |
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| Proton Pump Inhibitor (PPI) | | Proton Pump Inhibitors (PPI) |
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| ==Common Strengths==
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| *30 mg delayed-release capsules
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| *60mg delayed-release capsules
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| ==Drug Trade Name==
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| ==Drug Usage==
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| *Healing of erosive esophagitis (EE)
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| *Maintenance of healed erosive esophagitis (EE)
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| *Treatment of gastroesophageal reflux disease (GERD)
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| ==Mechanism of Action==
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| Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking gastric acid production in the stomach
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| ==Route of Administration==
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| Oral
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| ==Dosages ==
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| For adults and children aged 12 years and older, the typical dosage is:
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| Healing: 60 mg once daily for up to 8 weeks
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| Maintenance: 30 mg once daily for up to 6 months
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| GERD: 30 mg once daily for up to 4 weeks
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| ==Renal Dose Adjustments==
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| No renal dose adjustment recommended
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| ==Common Side Effects==
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| Diarrhea
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| Abdominal pain
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| Nausea
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| Vomiting
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| Flatulence
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| ==Serious Side Effects==
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| Bone fractures
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| Low blood magnesium levels
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| Clostridium difficile infection
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| Anaphylaxis
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| Vitamin B12 deficiency
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| ==Pharmacokinetics==
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| Dual-release mechanism
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| Onset of action: 1-2 hours (first peak), 4-5 hours (second peak);
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| Duration of action: Up to 24 hours, longer than other PPIs
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| ==Drug Precautions==
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| Pregnancy: Caution advised; Children: Safety not established; Elderly: Monitoring recommended
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| Breastfeeding: safety during breastfeeding is unclear
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| Children and Elderly: Approved for use in children aged 12 years and older; elderly patients may require monitoring due to potential increased sensitivity.
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| ==Monitoring Items==
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| Regular monitoring of magnesium and vitamin B12 levels
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| ==Drug Interactions==
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| Dexlansoprazole can interact with drugs metabolized by CYP2C19 and CYP3A4 enzymes
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| Interacts with methotrexate, digoxin, warfarin, certain antiretrovirals
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| ==FAQ==
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| ==How should I take the tablet?==
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| Take with or without food; swallow whole or sprinkle on apple sauce/water
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| ==What should I avoid while taking?==
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| Avoid highly acidic foods and grapefruit
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| ==What happens if I miss a dose?==
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| Take as soon as remembered unless close to next dose; do not double up on doses
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Gastrointestinal Drug
Drug class: Proton Pump Inhibitors (PPI)
Dexlansoprazole (中文: 右蘭索拉唑)
Drug Class
Proton Pump Inhibitors (PPI)
