Gabapentin

Catergory: Anticonvulsant medication

Pronunciation

Gabapentin 100mg

Gabapentin 300mg

Generic Name 藥名	HA Code 藥物代碼	Classification藥物分類
Gabapentin Capsule 100mg	GABA01	P1S1S3

Dosage

Epilepsy, By mouth: the initial oral dose is 300 mg on day 1, then 300mg twice daily on day 2, then 300mg 3 times daily on day 3. Alternatively, 300 mg three times daily on day 1; then increased according to response in steps of 300 mg every 2 -3 days. Usual dose: 0.9 – 3.6 g daily in 3 divided doses (Max. 4.8 g daily) Doses in children, for use as adjunctive therapy in children aged 6 years and over, and as monotherapy in those aged 12 years or over. • 6-12 years (adjunctive therapy): initially 10 mg/kg (max. 300 mg) once daily on day 1, then

                                                         10 mg /kg (max. 300mg) twice daily on day 2, then
                                                         10mg mg/kg (max. 300 mg) 3 times daily on day 3;
                                                         Usual dose 25 – 35 mg/kg daily in 3 divided doses; 
                                                         Max. 70 mg/kg daily in 3 divided doses.

Neuropathic Pain By mouth: 300 mg once daily on day 1, then

                  300 mg twice daily on day 2, then 
                 300 mg 3 times daily on day 3.

Alternatively, 300 mg 3 times daily on day 1, then increased according to response in steps of 300mg (in 3 divided doses) every 2-3 days up to max. 3.6 g daily. Migraine prophylaxis By mouth: initially 300 mg daily, increased according to response up to 2.4 g daily in divided doses.

As with other antiepileptics, withdrawal of gabapentin therapy or transition to or from another type of antiepileptic therapy should be made gradually to avoid precipitating an increase in seizure frequency. Withdrawal symptoms typically emerge within 12 hours to 7 days after stopping gabapentin. Commonly reported symptoms include agitation, confusion, disorientation, upset stomach and sweating. In some cases, patients experienced delirium and withdrawal seizures, which may only respond to the re-administration of gabapentin.