Etodolac

Generic Name 藥名	HA Code 藥物代碼	Classification藥物分類
Etodolac Capsule 200mg		P1S1S3

Mechanism of Action

Anti-inflammatory agent, Non-steroidal anti-inflammatory drug (NSAID) selective COX-2 inhibitor

Dosage

In the treatment of rheumatoid arthritis and osteoarthritis:

|Oral: initially 600 to 1000 mg daily in divided doses adjusted to response to a maintenance dose of 300 to 600 mg daily. Modified-release preparations are available for once-daily use in stable conditions.

|For treatment of acute pain:

|Oral: 200 to 400 mg every 6 to 8 hours, to a maximum of 1 g daily.

|Piroxicam has been given in similar doses as a rectal suppository or on a short-term basis by intramuscular injection. Piroxicam is one of the few NSAIDs that can be given parenteral routes.

|Administration in children

|Etodolac has been used in children with juvenile idiopathic arthritis. The following doses, given according to body-weight, are recommended for children aged 6 years and over:

• 20 to 30 kg: 400 mg once daily
• 31 to 45 kg: 600 mg once daily
• 46 to 60 kg: 800 mg once daily
• Over 60 kg: 1 g once daily

Side Effects

As with other NSAIDs the principal side effects include:

• Digestive complaints like nausea, heartburn, diarrhoea and bleeds or ulceration of the stomach
• Headache, dizziness, depression, drowsiness, insomnia
• Hearing disturbances such as tinnitus
• High blood pressure, oedema
• Skin reactions (including, albeit rarely, Stevens-Johnson syndrome and toxic epidermal necrolysis)
• And rarely, kidney failure, pancreatitis and liver damage

Etodolac is a preferential inhibitor of cyclo-oxygenase-2 (COX-2) and consequently it has less gastric toxicity than the non-selective NSAIDs such as naproxen.

Pharmacokinetics

Peak plasma concentrations occur within about 2 hours of an oral dose. The plasma elimination half-life is about 7 hours.

Drug Management

Monitoring: