Memantine: Difference between revisions
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=====Why is donepezil taken at night?===== | =====Why is donepezil taken at night?===== | ||
Donepezil is taken at night because it can cause irregular or slow heartbeat for some patients, which can cause fainting. When it is taken at bedtime, affected patients will be able to sleep through those side effects. | Donepezil is taken at night because it can cause irregular or slow heartbeat for some patients, which can cause fainting. When it is taken at bedtime, affected patients will be able to sleep through those side effects. | ||
==Drug Management== | |||
'''Monitoring: | |||
*No routine monitoring required for toxicity | |||
Monitoring Efficacy | |||
*Activities of daily living and cognitive functioning improvements | |||
*Slowing in the progression of decline in cognitive function and memory impairment | |||
*It may take months for any noticeable improvement | |||
'''Caution : | |||
*Genitourinary conditions: Conditions that raise urine pH may decrease the urinary elimination of memantine | |||
*Hepatic impairment: Precaution use in severe hepatic impairment; effects of impairment on pharmacokinetics have not been established | |||
'''Contraindications: | |||
It is contraindicated in patients with a known hypersensitivity to memantine. | |||
==FAQ== | |||
==== How should I take Memantine hydrochloride ?==== | |||
Memantine hydrochloride should be administered orally once a day. To benefit from your medicine you should take it daily around the same time. The tablets should be swallowed with plenty of water. The tablets can be taken with or without food. | |||
====What should I avoid while taking?==== | |||
Avoid abruptly discontinue the medication. | |||
==== What happen if I overdose?==== | |||
Contact your primary care doctor. | |||
If emergency situation, call 999 | |||
==== What happen if I miss a dose?==== | |||
Take it as soon as you | |||
remember. If it is near the time | |||
of the next dose, skip the missed | |||
dose. Take your next dose at the | |||
regular time. Do not double the | |||
dose to catch up. | |||
Revision as of 02:51, 30 September 2020
Introduction
Memantine, is a glutamate receptor antagonist. It is used to treat moderate to severe Alzheimer’s disease.
| Generic Name 藥名 | HA Code 藥物代碼 | Classification藥物分類 |
|---|---|---|
| Memantine HCL Tablet 10mg | MEMA01 | P1S1S3 |
Mechanism of Action
Glutamate receptor antagonist
Dosage
By Oral: initially 5 mg once daily, increased in steps of 5 mg at weekly intervals to a maximum dose of 20 mg daily.
Clinical benefit should be assessed on a regular basis.
Side Effects=
Common side effects include
- Constipation
- Dizziness
- Headache
- Hallucinations
- confusuion
- sleepiness
Serious side effects may include:
- Blood clots
- Psychosis
- Heart failure
Pharmacokinetics
| Oral bioavailability | Memantine is well absorbed after oral doses. It is about 45% bound to plasma proteins. |
|---|---|
| Onset of action | Peak plasma concentrations are achieved in 3 to 8 hours |
| Metabolism | Partial hepatic metabolism. |
| Elimination half-life | Ranges from 60 to 100 hours |
How long does it take for donepezil to take effect?
Donepezil may take as long as 12 weeks to begin working.
What time of day should donepezil be taken?
It is usually taken once a day with or without food, just before bedtime. Take donepezil at around the same time every day.
Why is donepezil taken at night?
Donepezil is taken at night because it can cause irregular or slow heartbeat for some patients, which can cause fainting. When it is taken at bedtime, affected patients will be able to sleep through those side effects.
Drug Management
Monitoring:
- No routine monitoring required for toxicity
Monitoring Efficacy
- Activities of daily living and cognitive functioning improvements
- Slowing in the progression of decline in cognitive function and memory impairment
- It may take months for any noticeable improvement
Caution :
- Genitourinary conditions: Conditions that raise urine pH may decrease the urinary elimination of memantine
- Hepatic impairment: Precaution use in severe hepatic impairment; effects of impairment on pharmacokinetics have not been established
Contraindications: It is contraindicated in patients with a known hypersensitivity to memantine.
FAQ
How should I take Memantine hydrochloride ?
Memantine hydrochloride should be administered orally once a day. To benefit from your medicine you should take it daily around the same time. The tablets should be swallowed with plenty of water. The tablets can be taken with or without food.
What should I avoid while taking?
Avoid abruptly discontinue the medication.
What happen if I overdose?
Contact your primary care doctor. If emergency situation, call 999
What happen if I miss a dose?
Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
