Sodium Valproate

Introduction

Sodium valproate or valproic acid is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as an add-on therapy for absence seizures, partial seizures, and generalized tonic-clonic seizures. It's also used to prevent migraine headaches and help with manic episodes in bipolar disorder.

Generic Name 藥名	HA Code 藥物代碼	Classification藥物分類
Sodium valproate Solution	VALP03	P1S1S3
Enteric-coated tablet	VALP02	P1S1S3
CR tablet 200 mg	VALP06	P1S1S3
CR tablet 300 mg	VALP07	P1S1S3
CR tablet 500 mg	VALP05	P1S1S3

Mechanism of Action

Anticonvulsant medication. It blocks voltage-gated sodium channels and increased brain levels of gamma-aminobutyric acid.

Dosage

1. Epilepsy

Oral: Initially 600 mg daily in 1-2 divided doses increase in steps of 150 -300 mg every 3 days maintenance 1-2g daily, maximum 2.5g daily

Administration in child:

Child 1 month-11 years: initially 10-15 mg/kg daily in 1-2 divided doses, (max per dose 600mg.) maintenance 25-30mg/kg daily in 2 divided doses, doses up to 60mg/kg daily may be used. Monitor hematological parameters if dose exceed 40mg/kg

Child 12-17 years: initially 600 mg daily in 1-2 divided doses increase in steps of 150 -300 mg every 3 days maintenance 1-2g daily, maximum 2.5g daily

2. Migraine prophylaxis:

Oral: initially 200mg twice daily, increased if needed to 1.2-2.5g daily in divided dose.

3. Mania

Initially 750mg daily in 1-2 divided doses, usually dose 1-2g daily in 1-2 divided doses. Carefully monitor if dose exceed 45mg/kg