Pregabalin

Pronunciation

Pregabalin 150mg

Pregabalin 25mg

Pregabalin 50mg

Introduction

Gabapentin is an anticonvulsant medication:

• Peripheral and central neuropathic pain
• Used as an adjunctive therapy for focal seizures with or without secondary generalization.
• Generalized anxiety disorder

Mechanism of Action

Anticonvulsant medication. It inhibits the alpha 2-delta subunit of voltage-dependent calcium channels.

Generic Name 藥名	HA Code 藥物代碼	Classification藥物分類
Pregabalin Capsule 25mg	PREG15	P1S1S3

Dosage

Epilepsy

By mouth	the initial oral dose is 25 mg twice daily, increased at weekly intervals in steps of 50 mg daily to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to max. 600 mg daily in 2-3 divided doses.

Neuropathic Pain

By mouth	initially 150 mg daily in 2-3 divided doses, increased if necessary after 3-7 days to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to max. 600 mg daily in 2-3 divided doses.

Alternatively, 300 mg 3 times daily on day 1, then increased according to response in steps of 300mg (in 3 divided doses) every 2-3 days up to max. 3.6 g daily.

Generalized anxiety disorder

By mouth	initially 150 mg daily in 2-3 divided doses, increased if necessary at weekly intervals in steps of 150 mg daily; max. 600 mg daily in 2-3 divided doses.

As with other antiepileptics, withdrawal of prgabalin therapy or transition to or from another type of antiepileptic therapy should be made gradually to avoid precipitating an increase in seizure frequency.

Side Effects

Adverse drug reactions associated with the use of pregabalin include:

Very common (>10% of people with pregabalin)	Dizziness, drowsiness
Common (1-10% of people with pregabalin)	Blurred vision, diplopia,	Increased appetite and subsequent weight gain	Euphoria	Confusion	Memory impairment	Tremors	Vertigo	Dry mouth and constipation	Vomiting and flatulence	Erectile dysfunction	Peripheral edema	Aataxia
Morphine	Morphine reduces the clearance of gabapentin; patients receiving both drugs should be monitored for signs for CNS depression and doses should be reduced accordingly.