Pregabalin: Difference between revisions
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Adverse drug reactions associated with the use of pregabalin include: | Adverse drug reactions associated with the use of pregabalin include: | ||
{| class="wikitable" | |||
|'''Very common''' (>10% of people with lamotrigine) | |||
|Dizziness, drowsiness | |Dizziness, drowsiness | ||
|- | |- | ||
|'''Common''' (1-10% of people with lamotrigine) | |||
|Blurred vision, diplopia, | |Blurred vision, diplopia, | ||
Ataxia | |||
Aggression | |||
Agitation | |||
Back pain | |||
Tremor | |||
Nausea and vomiting | |||
|- | |- | ||
| | |Rare (<0.1% of people with lamotrigine) | ||
| | |Blood disorders, anaemia, leucopenia | ||
Exacerbation of Parkinson’s disease | |||
Hallucination | |||
Hepatic failure | |||
Hypersensitivity syndrome | |||
Lupus erythematosus-like reactions | |||
|} | |} | ||
Revision as of 22:23, 5 October 2020
Pronunciation
Pregabalin 150mg
Pregabalin 25mg
Pregabalin 50mg
Introduction
Gabapentin is an anticonvulsant medication:
- Peripheral and central neuropathic pain
- Used as an adjunctive therapy for focal seizures with or without secondary generalization.
- Generalized anxiety disorder
Mechanism of Action
Anticonvulsant medication. It inhibits the alpha 2-delta subunit of voltage-dependent calcium channels.
| Generic Name 藥名 | HA Code 藥物代碼 | Classification藥物分類 |
|---|---|---|
| Pregabalin Capsule 25mg | PREG15 | P1S1S3 |
Dosage
Epilepsy
| By mouth | the initial oral dose is 25 mg twice daily, increased at weekly intervals in steps of 50 mg daily to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to max. 600 mg daily in 2-3 divided doses. |
|---|
Neuropathic Pain
| By mouth | initially 150 mg daily in 2-3 divided doses, increased if necessary after 3-7 days to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to max. 600 mg daily in 2-3 divided doses. |
|---|
Alternatively, 300 mg 3 times daily on day 1, then increased according to response in steps of 300mg (in 3 divided doses) every 2-3 days up to max. 3.6 g daily.
Generalized anxiety disorder
| By mouth | initially 150 mg daily in 2-3 divided doses, increased if necessary at weekly intervals in steps of 150 mg daily; max. 600 mg daily in 2-3 divided doses. |
|---|
As with other antiepileptics, withdrawal of prgabalin therapy or transition to or from another type of antiepileptic therapy should be made gradually to avoid precipitating an increase in seizure frequency.
Side Effects
Adverse drug reactions associated with the use of pregabalin include:
| Very common (>10% of people with lamotrigine) | Dizziness, drowsiness |
| Common (1-10% of people with lamotrigine) | Blurred vision, diplopia,
Ataxia Aggression Agitation Back pain Tremor Nausea and vomiting |
| Rare (<0.1% of people with lamotrigine) | Blood disorders, anaemia, leucopenia
Exacerbation of Parkinson’s disease Hallucination Hepatic failure Hypersensitivity syndrome Lupus erythematosus-like reactions |
