Phenobarbitone

Phenobarbital(中文: 苯巴比妥), also known as phenobarbitone or phenobarb, is a medication of the barbiturate type. It is used to control all forms of epilepsy except absence seizures. It is also used as part of the emergency management of acute seizures including status epilepticus. It usually begins working within 5 minutes when used intravenously and 30 minutes when administered by mouth. Its effects last for between 4 hours and 2 days.

Pronunciation

Phenobarbitone 30mg

Phenobarbitone 60mg

Drug Names

Generic Name 藥名	HA Code 藥物代碼	Classification藥物分類
Phenobarbitone Tablet 30mg	PHEN08	P1S1S3
Phenobarbitone Tablet 60mg	PHEN09	P1S1S3

Mechanism of Action

Anticonvulsant medication. It binds to GABAa receptor subunits. Through this interaction, phenobarbitone increases the flow of chloride ions into the neuron which decreases the excitability of the post-synaptic neuron. Furthermore, direct blockade of excitatory glutamate signaling also contribute to the hypnotic/anticonvulsant effect.

Dosage

The dose should be adjusted to the needs of the individual patient to achieve control of seizures; this usually requires plasma concentrations of 15 to 40 micrograms/ml. However, plasma-drug concentration monitoring is less useful than with other drugs because tolerance occurs.

Epilepsy

By Mouth ADULT: 60 – 180 mg once daily, dose to be taken at night CHILD 1 month – 11 years: Initially 1 – 1.5 mg/kg twice daily, then Increased in steps of 2 mg/kg daily as required; Maintenance 2.5 – 4 mg/kg in 1 – 2 times daily CHILD 12 – 17 years: 60 – 180 mg once daily, dose to be taken at night

Status epilepticus

By intravenous injection ADULT: 10 mg/kg (max. per dose 1g), dose to be administered at a rate not more than 100 mg/minute, injection to be diluted 1 in 10 with water for injections. By slow intravenous injection CHILD 1 month – 11 years: Initially 20 mg/kg, dose to be administered at a rate no faster than 1 mg/kg/minute, then 2.5 – 5 mg/kg 1 -2 times a day CHILD 12 – 17 years: Initially 20 mg/kg (max. per dose 1g), dose to be administered at a rate no faster than 1 mg/kg/minute, then 300 mg twice daily

Side Effects

Adverse drug reactions associated with the use of topiramate include:

!style="text-align: left"| Very common (>10% incidence) |*sedation

• hypnosis

|- !style="text-align: left"| Common (1-10% incidence) |*Central nervous systems effects, such as dizziness, nystagmus and ataxia

• Hyperactivity in the elderly and in children
• hepatitis
• Impaired cognition
• Impaired memory
• Depression
• Prolonged use can occasionally result in folate deficiency
• At high doses typical barbiturate-induced respiratory depression may become severe

!style="text-align: left"| Rare (<0.1% of incidence) |*Stevens-Johnson syndrome

• Suicidal ideation
• Toxic epidermal necrolysis

|}

Phenobarbitone therapy

Overdose

Overdosage can prove fatal; toxic effects include:

• Coma
• Slow or shallow breathing, weak pulse
• Hypotension
• Renal failure