Sulpiride

Drug Class: Antipsychotics, typical ; Antipsychotics, 1st Generation Sulpiride (中文:[[ ]])is a typical antipsychotic or 1st Generation antipsychotic medication. It is used in the treatment of psychosis associated with schizophrenia and major depressive disorder. In low dosage, it is used for anxiety and mild depression.

Pronunciation

Sulpiride 200mg

Sulpiride 50mg

Drug Names

Generic Name 藥名	HA Code 藥物代碼	Classification藥物分類
Sulpiride Cap 50 mg	SULP19	P1S1S3
Sulpiride Tab 200 mg	SULP20	P1S1S3

Mechanism of Action

Sulpiride is a selective antagonist at dopamine D2, D3 and 5-HT1A receptors. The presumed effectiveness of antipsychotic drugs relied on their ability to block dopamine receptors. This assumption arose from the dopamine hypothesis that maintains that both schizophrenia and bipolar disorder are a result of excessive dopamine activity.

Dosage

Indication	Dose
Schizophrenia with predominantly negative symptoms (flattening of affect, poverty of speech, apathy, as well as depression)	By mouth ADULT: 200 – 400 mg twice daily. Maximum 800 mg per day ELDERLY or debilitated patients: Lower initial dose to be given Increased gradually according to response
Schizophrenia with mainly positive symptoms (hallucinations, delusions, incongruity of speech) Respond to higher doses	By mouth ADULT: 200 – 400 mg twice daily Maximum 2.4 g per day ELDERLY or debilitated patients: Lower initial dose to be given Increased gradually according to response