Category:Anticoagulants: Difference between revisions
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Indirect anticoagulants act by depressing the hepatic vitamin K-dependent synthesis of coagulation factors II (prothrombin), VII, IX, and X, and of the anticoagulant protein C and its cofactor protein S. Warfarin, a coumarin, is the main drug used. | Indirect anticoagulants act by depressing the hepatic vitamin K-dependent synthesis of coagulation factors II (prothrombin), VII, IX, and X, and of the anticoagulant protein C and its cofactor protein S. Warfarin, a coumarin, is the main drug used. | ||
Example: | |||
*Riavroxaban | |||
*Apixaban | |||
*Edoxaban | |||
Revision as of 03:29, 27 June 2024
Anticoagulants（中文： 抗凝血藥）
Anticoagulants are used in the treatment and prophylaxis of thromboembolic disorders.
Direct anticoagulants
Rivaroxaban, apixaban, and edoxaban are orally active factor Xa inhibitors. The direct thrombin inhibitors bind to the active thrombin site and inhibit both free and clot-bound thrombin. Dabigatran, given orally as the prodrug dabigatran etexilate, is used in the prophylaxis of venous thromboembolism.
Indirect anticoagulants
Indirect anticoagulants act by depressing the hepatic vitamin K-dependent synthesis of coagulation factors II (prothrombin), VII, IX, and X, and of the anticoagulant protein C and its cofactor protein S. Warfarin, a coumarin, is the main drug used.
Example:
- Riavroxaban
- Apixaban
- Edoxaban
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