Bupropion

Antidepressant Drug

Drug class: Atypical Antidepressants

Bupropion (WELLBUTRIN)（中文：安非他酮）

Common Strengths of Bupropion

Bupropion are available in the following strengths:

• Immediate-release: 75 mg, 100 mg
• Sustained-release (SR): 100 mg, 150 mg, 200 mg
• Extended-release (XL): 150 mg, 300 mg, 450 mg

Drug Trade Names of Bupropion

• Wellbutrin
• Wellbutrin SR
• Wellbutrin XL
• Zyban

Drug Usage

• Major depressive disorder (MDD)
• Seasonal affective disorder (SAD): Bupropion is used to manage seasonal patterns of depression.
• Smoking cessation: Under the brand name Zyban, it helps reduce nicotine cravings and withdrawal symptoms.

Mechanism of Action

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI). It works by inhibiting the reuptake of norepinephrine and dopamine, two neurotransmitters involved in mood regulation and reward pathways. By preventing their reabsorption, bupropion increases the levels of these neurotransmitters in the brain, which can help alleviate symptoms of depression and aid in smoking cessation.

Route of Administration

Oral

Dosages

Major depressive disorder (MDD):

• Immediate-release: 100 mg twice daily, up to 450 mg/day
• Sustained-release: 150 mg twice daily, up to 400 mg/day
• Extended-release: 150 - 300 mg once daily, up to 450 mg/day

Renal dose based on eGFR:

• eGFR 30 - 89 mL/min: Reduce dose by 25 - 50%
• eGFR <30 mL/min: Reduce dose by 50% or more