Dexlansoprazole (DEXILANT)

Gastrointestinal Drug

Drug class: Proton Pump Inhibitors (PPI)

Dexlansoprazole (中文: 右蘭索拉唑)

Drug Class

Proton Pump Inhibitors (PPI)

Common Strengths of Dexlansoprazole capsule

Dexlansoprazole capsule are available in the following strengths:

• 30 mg delayed-release capsules

• 60mg delayed-release capsules

Drug Trade Names of Dexlansoprazole capsule

Dexilant

Drug Usage

Dexlansoprazole is used for:

• Healing of erosive esophagitis (EE)

• Maintenance of healed erosive esophagitis (EE)

• Treatment of gastroesophageal reflux disease (GERD)

Mechanism of Action

Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking gastric acid production in the stomach

Route of Administration

Oral

Dosages

For adults and children aged 12 years and older, the typical dosage is:

Healing: 60 mg once daily for up to 8 weeks

Maintenance: 30 mg once daily for up to 6 months

GERD: 30 mg once daily for up to 4 weeks

Renal Dose Adjustments

No renal dose adjustment recommended

Side Effects

Frequency	Adverse reactions
Common Side Effects
	Diarrhea
	Abdominal pain
	Nausea
	Vomiting
	Flatulence
Serious Side Effects
	Bone fractures
	Low blood magnesium levels
	Clostridium difficile infection
	Anaphylaxis
	Vitamin B12 deficiency

Pharmacokinetics

Dual-release mechanism

Onset of action: 1-2 hours (first peak), 4-5 hours (second peak);

Duration of action: Up to 24 hours, longer than other PPIs

Drug Precautions

Pregnancy: Caution advised; Children: Safety not established; Elderly: Monitoring recommended

Breastfeeding: safety during breastfeeding is unclear

Children and Elderly: Approved for use in children aged 12 years and older; elderly patients may require monitoring due to potential increased sensitivity.

Monitoring Items

Regular monitoring of magnesium and vitamin B12 levels

Drug Interactions

Dexlansoprazole can interact with drugs metabolized by CYP2C19 and CYP3A4 enzymes

Interacts with methotrexate, digoxin, warfarin, certain antiretrovirals

FAQ

How should I take the tablet?

Take with or without food; swallow whole or sprinkle on apple sauce/water

What should I avoid while taking?

Avoid highly acidic foods and grapefruit

What happens if I miss a dose?

Take as soon as remembered unless close to next dose; do not double up on doses