Diclofenac Sodium

Pronunciation

Diclofenac sodium 100mg

Diclofenac sodium 25mg

Generic Name 藥名	HA Code 藥物代碼	Classification藥物分類
Diclofenac Potassium Tablet 50mg		P1S1S3

Mechanism of Action

Non-opioid Analgesic (NSAID) Anti-inflammatory agent, Nonselective COX inhibitor, inhibits COX-1 and COX-2 with relative equipotency

Dosage

Usual oral dose for painful conditions:

Oral: 25 to 50 mg every 6 to 8 hours to a maximum of 150 mg daily.

Deep intramuscular: 75 mg once daily, if required in severe conditions, 75 mg twice daily.

Bolus intravenous: 75 mg may be given over 30 to 120 minutes. The dose may be repeated once after 4 to 6 hours if necessary.

Diclofenac sodium 0.1% eye drops is used in various situations:

• For the prevention of intra-operative miosis during cataract surgery. It is instilled in the appropriate eye 4 times during the 2 hours before surgery
• For the treatment of postoperative inflammation after cataract surgery. It is instilled 4 times daily for up to 28 days starting 24 hours after surgery
• For pain control after accidental trauma, one drop is instilled 4 times daily for up to 2 days
• To relieve symptoms of seasonal allergic conjunctivitis, one drop is instilled 4 times daily as necessary

Topical

Diclofenac dimethylamine is used topically as a gel for the local symptomatic relief of pain and inflammation. It is applied to the affected site 3 or 4 times daily.

Administration in children

In children aged 6 months to 17 years,

for rheumatic disease, Oral: 3 to 5 mg/kg daily in 2 or 3 divided doses.

For soft-tissue disorders, oral: 0.3 to 1 mg/kg (maximum 50 mg) given 3 times daily.

Rectal: those weighing 8 to 11 kg, 12.5 mg twice daily and heavier children 1 mg/kg three times daily. Intravenous infusion or deep intramuscular injection: 0.3 to 1 mg/kg (maximum 50 mg) given 3 times daily, for up to 2 days for postoperative pain.

Regardless of route or indication, a maximum daily dose of 150 mg should not exceeded.