Etoricoxib

Catergory: Etoricoxib

Generic Name 藥名	HA Code 藥物代碼	Classification藥物分類
Arcoxia Tablet 120 mg		P1S1S3

Mechanism of Action

Anti-inflammatory agent, Non-steroidal anti-inflammatory drug (NSAID) Selective COX-2 inhibitor

Dosage

For osteoarthritis

Oral: 30 mg daily once daily, increased to 60 mg once daily if necessary.

For rheumatoid arthritis and ankylosing spondylitis

Oral: 60 mg once daily, increased to 90 mg once daily if necessary.

For gouty arthritis

Oral: 120 mg once daily.

Such higher doses should only be used for acute symptomatic period and for a maximum of 8 days.

For postoperative dental pain

Oral: 90 mg once daily for a maximum of 3 days.

Administration in hepatic impairment

Mild hepatic impairment: 60 mg once daily

Moderate hepatic impairment: 60 mg every other day or 30 mg once daily.

Etoricoxib should not be given to patients with severe hepatic impairment.

Side Effects

Common side effects include:

• Abdominal pain, nausea and diarrhea.

Serious side effects may include:

• Heart attacks
• Strokes
• Gastrointestinal perforation
• Gastrointestinal bleeding
• Kidney failure
• Anaphylaxis

It is generally accepted that COX-2 inhibitor may cause less gastrotoxicity than that seen with the non-selective inhibition of the traditional NSAIDs. However, reports that upper gastrointestinal perforation, ulceration and bleeds have occurred with etoricoxib treatment and should not be used in patients with active gastrointestinal ulceration or bleeding.