Memantine
Introduction
Memantine, is a glutamate receptor antagonist. It is used to treat moderate to severe Alzheimer’s disease.
| Generic Name 藥名 | HA Code 藥物代碼 | Classification藥物分類 |
|---|---|---|
| Memantine HCL Tablet 10mg | MEMA01 | P1S1S3 |
Mechanism of Action
Glutamate receptor antagonist
Dosage
By Oral: initially 5 mg once daily, increased in steps of 5 mg at weekly intervals to a maximum dose of 20 mg daily.
Clinical benefit should be assessed on a regular basis.
Side Effects=
Common side effects include
- Constipation
- Dizziness
- Headache
- Hallucinations
- confusuion
- sleepiness
Serious side effects may include:
- Blood clots
- Psychosis
- Heart failure
Pharmacokinetics
| Oral bioavailability | Memantine is well absorbed after oral doses. It is about 45% bound to plasma proteins. |
|---|---|
| Onset of action | Peak plasma concentrations are achieved in 3 to 8 hours |
| Metabolism | Partial hepatic metabolism. |
| Elimination half-life | Ranges from 60 to 100 hours |
How long does it take for donepezil to take effect?
Donepezil may take as long as 12 weeks to begin working.
What time of day should donepezil be taken?
It is usually taken once a day with or without food, just before bedtime. Take donepezil at around the same time every day.
Why is donepezil taken at night?
Donepezil is taken at night because it can cause irregular or slow heartbeat for some patients, which can cause fainting. When it is taken at bedtime, affected patients will be able to sleep through those side effects.
