Bromazepam
From SEHK Wiki
Introduction
Bromazepam is an intermediate-acting benzodiazepine. It is used in the short-term treatment of anxiety disorders, occuring alone or associated with insomnia.
| Generic Name 藥名 | HA Code 藥物代碼 | Classification藥物分類 |
|---|---|---|
| Bromazepam Tablet 1.5 mg | BROM01 | DDA |
| Bromazepam Tablet 3 mg | BROM02 | DDA |
Pronunciation
Mechanism of Action
- Bromazepam is a benzodiazepine.
- Gama-Aminobutyric acid (GABA) is an inhibitory neurotransmitter, acting on the GABA receptors in the central nervous system (CNS), thus inhibiting the nerve impulses.
- Bromazepam acts on the benzodiazepine receptors in the brain and the spinal cord. Benzodiazepine receptors in the CNS are linked with GABA receptors as a complex.
- Bromazepam by binding to the benzodiazepine receptors results in activation of the GABA-benzodiazepine receptor complex, resulting in inhibition of nerve impulses, overall depression of brain and spinal cord.
- Thus Bromazepam use helps to promote muscle relaxation, reduce anxiety, control of convulsions and promote sleep.
Dosage
| Short-term use in anxiety | By mouth
When the total dose is low (eg. 3 or 6 mg), to give the total dose in the evening |
|---|
Side Effects
Sedative drugs, including alprazolam, have been associated with an increased risk of death.
Possible side effects include:
| Very common (>10% of incidence)
or Common (1-10% of incidence) |
|
|---|---|
| Infrequent (0.1 -1% of incidence) |
|
| Rare (<0.1% of incidence) |
|
Minor elevations of liver enzymes occurred in about 3% of patients.
Overdosage can produce CNS depression and coma.
Paradoxical reactions
Although unusual, the following paradoxical reactions have been shown to occur:
- aggression, rage
- mania, agitation, and restlessness
- hallucinations, inappropriate behavior
- twitches and tremor
