Perindopril
Pronunciation
Perindopril 4mg (ACERTIL 4mg)
| Generic Name: | Perindopril |
|---|---|
| Class: | Cardiovascular Drug |
| Subclass: | ACE inhibitor |
| Legal Classification: | P1S1S3 |
Drug Names
| Generic Name 藥物化學名稱 | HA Code 藥物代碼 | Legal Classification法律藥物分類 | Brand Name 品牌名稱 |
|---|---|---|---|
| Perindopril Tertbutylamine Tab 2mg | PERI28 | P1S1S3 | ACERTIL AR Tablet 5mg |
| Perindopril Tertbutylamine Tab 4mg | PERI17 | P1S1S3 | ACERTIL AR Tablet 10mg |
| Perindopril Arginine Tab 5mg | PERI29 | P1S1S | ACERTIL PLUS TAB 2.5mg/0.625mg (perindopril arginine 5 mg, indapamide 0.625mg) |
| Perindopril Arginine Tab 10mg | ACERTIL PLUS TAB 5MG/1.25MG (perindopril arginine 5 mg, indapamide 1.25mg) | ||
| ACERTIL PLUS TAB 10mg/2.5mg (perindopril arginine 10 mg, indapamide 2.5mg) |
Mechanism of Action
Perindopril is an inhibitor of angiotensin-I converting enzyme (ACE inhibitor). The beneficial effects of ACE inhibitors appear to result primarily from the suppression of the plasma renin-angiotensin-aldosterone system. Renin is synthesized by the kidneys and released into the circulation where it converts angiotensinogen to angiotensin-I. Angiotensin-I is then converted by angiotensin converting enzyme to angiotensin-II. Angiotensin-II is a potent vasoconstrictor responsible for arterial vasoconstriction and increased blood pressure, as well as for stimulation of the adrenal gland to secrete aldosterone. Inhibition of ACE results in decreased plasma angiotensin-II, which leads to decreased vasopressor activity and to reduced aldosterone secretion. The latter decrease may result in an increase in serum potassium concentration. Perindopril is used in the treatment of hypertension and heart failure. Perindopril helps to reduce the risk of future strokes and heart attacks. It also improves your survival if you are taking it following a heart attack or heart surgery. It works by widening your blood vessels and making it easier for your heart to pump blood around your body. This can improve the symptoms of heart failure.
Perindopril can be used alone or in combination with other antihypertensive agent such as indapamide.
Route of Administration
Perindopril is administered orally in a single daily dose
Dosage
Dose for perindopril Tertbutylamine
- Hypertension - 4mg once a day (the maximum dose is 8 mg once daily)
- Heart failure – 4mg once a day
- After a heart attack – 8mg once a day
Dose for perindopril Arginine
- Hypertension - 5mg once a day (the maximum dose is 10 mg once daily)
- Heart failure – 5mg once a day
- After a heart attack – 10mg once a day
When will I feel better? Perindopril starts to work within a few hours to reduce high blood pressure, but it may take up to a month to achieve its full effect.
If you are taking perindopril for heart failure, it may take weeks, even months, before you feel better.
