Category:Anticoagulant Drug

Anticoagulant Drug（中文： 抗凝血藥）

Anticoagulants are used in the treatment and prophylaxis of thromboembolic disorders.

Direct anticoagulants

Rivaroxaban, apixaban, and edoxaban are orally active factor Xa inhibitors. The direct thrombin inhibitors bind to the active thrombin site and inhibit both free and clot-bound thrombin. Dabigatran, given orally as the prodrug dabigatran etexilate, is used in the prophylaxis of venous thromboembolism.

Indirect anticoagulants

Indirect anticoagulants act by depressing the hepatic vitamin K-dependent synthesis of coagulation factors II (prothrombin), VII, IX, and X, and of the anticoagulant protein C and its cofactor protein S. Warfarin, a coumarin, is the main drug used.

Example:

• Riavroxaban
• Apixaban
• Edoxaban