Celecoxib
Introduction
Celecoxib is a nonsteroidal anti-inflammatory drug, an NSAID, selectively inhibit cyclo-oxygenase-2 (COX-2). As an NSAID, celecoxib is an analgesic, anti-inflammatory and antipyretic.
Clinical indications for indomethacin include:
- rheumatoid arthritis
- alkylosing spondylitis
- osteoarthritis
- gouty arthritis
- acute painful shoulder bursitis or tendinitis
It is also be used in menstrual pain, headaches, dental pain, postoperative and postpartum pain.
Mechanism of Action
- Anti-inflammatory agent
- Non-steroidal anti-inflammatory drug (NSAID)
- Highly selective COX-2 inhibitor
Dosage
For osteoarthritis
Oral: 200 mg daily given as a single dose or in 2 divided doses. If necessary a dose of 200 mg twice daily may be used.
For rheumatoid arthritis
Oral: 100 to 200 mg given twice daily.
For ankylosing spondylitis
Oral: an initial dose of 200 mg daily, as a single or in 2 divided doses. In the USA, the dose may be increased to 400 mg daily after 6 weeks, although if no response is seen at this dose a further 6 weeks, alternative treatments should be considered.
For pain and dysmenorrhea
Oral: an initial dose of 400 mg followed by an additional dose of 200 mg, if necessary, is recommended on the first day; thereafter the dose is 200mg twice daily. In patients with hepatic impairment and in those also taking fluconazole, a potent inhibitor of the cytochrome P450 isoenzyme CYP2C9, the dose of celecoxib should be reduced to half the recommended dose.
