Dexlansoprazole (DEXILANT)
Drug class: Proton Pump Inhibitors (PPI)
Dexlansoprazole (中文: 右蘭索拉唑)
Drug Class
Proton Pump Inhibitor (PPI)
Common Strengths
- 30 mg delayed-release capsules
- 60mg delayed-release capsules
Drug Trade Name
Drug Usage
- Healing of erosive esophagitis (EE)
- Maintenance of healed erosive esophagitis (EE)
- Treatment of gastroesophageal reflux disease (GERD)
Mechanism of Action
Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking gastric acid production in the stomach
Route of Administration
Oral
Dosages
For adults and children aged 12 years and older, the typical dosage is:
Healing: 60 mg once daily for up to 8 weeks
Maintenance: 30 mg once daily for up to 6 months
GERD: 30 mg once daily for up to 4 weeks
Renal Dose Adjustments
No renal dose adjustment recommended
Common Side Effects
Diarrhea
Abdominal pain
Nausea
Vomiting
Flatulence
Serious Side Effects
Bone fractures
Low blood magnesium levels
Clostridium difficile infection
Anaphylaxis
Vitamin B12 deficiency
Pharmacokinetics
Dual-release mechanism
Onset of action: 1-2 hours (first peak), 4-5 hours (second peak);
Duration of action: Up to 24 hours, longer than other PPIs
Drug Precautions
Pregnancy: Caution advised; Children: Safety not established; Elderly: Monitoring recommended
Breastfeeding: safety during breastfeeding is unclear
Children and Elderly: Approved for use in children aged 12 years and older; elderly patients may require monitoring due to potential increased sensitivity.
Monitoring Items
Regular monitoring of magnesium and vitamin B12 levels
Drug Interactions
Dexlansoprazole can interact with drugs metabolized by CYP2C19 and CYP3A4 enzymes
Interacts with methotrexate, digoxin, warfarin, certain antiretrovirals
FAQ
How should I take the tablet?
Take with or without food; swallow whole or sprinkle on apple sauce/water
What should I avoid while taking?
Avoid highly acidic foods and grapefruit
What happens if I miss a dose?
Take as soon as remembered unless close to next dose; do not double up on doses
