Rabeprazole
Rabeprazole
Pronunciation
Rabeprazole 20mg
Drug Class
Rabeprazole belongs to the class of medications known as proton pump inhibitors (PPIs). These drugs work by inhibiting gastric acid secretion.
Common Strengths
Rabeprazole is available in the following strengths:
- 10 mg delayed-release tablets
- 20 mg delayed-release tablets
Drug Trade Name
Rabeprazole is marketed under the trade name PARIET.
Drug Usage
Rabeprazole is primarily used for:
- Healing of erosive or ulcerative gastroesophageal reflux disease (GERD)
- Maintenance of healing of erosive or ulcerative GERD
- Treatment of symptomatic GERD
- Healing of duodenal ulcers
- Eradication of Helicobacter pylori to reduce the risk of duodenal ulcer recurrence
- Treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome
Mechanism of Action
Rabeprazole works by selectively and irreversibly inhibiting the H^+, K^+-ATPase enzyme system (the proton pump) at the secretory surface of gastric parietal cells. This inhibition reduces gastric acid secretion, thereby alleviating symptoms associated with excess stomach acid.
Route of Administration
Rabeprazole is administered orally, available as delayed-release tablets and capsules.
Dosages for Normal People
The typical dosage for adults is:
- GERD treatment: 20 mg once daily for up to 8 weeks.
For renal dosing based on eGFR:
- No specific renal dose adjustment is typically required, but caution is advised in patients with severe renal impairment.
Side Effects: Common and Serious Side Effects
Common side effects include:
- Constipation
- Weakness
- Throat inflammation
Serious side effects may include:
- Osteoporosis-related fractures
- Low blood magnesium levels
- Clostridioides difficile infection in the colon
- Pneumonia
Pharmacokinetics
Rabeprazole has an absolute bioavailability of approximately 52%. It undergoes hepatic metabolism and has a half-life of about 1 to 2 hours. The onset of action occurs within 1 hour, with a duration of action lasting up to 24 hours.
Drug Precautions
Pregnancy
The safety of rabeprazole during pregnancy is unclear; it should only be used if clearly needed.
Breastfeeding
It is unknown whether rabeprazole passes into breast milk; caution is advised.
Children and Elderly
Rabeprazole can be used in children aged 12 years and older for GERD treatment. Use in elderly patients may require careful monitoring due to potential increased sensitivity to side effects.
Monitoring Items
Patients on rabeprazole should be monitored for:
- Signs of gastrointestinal bleeding
- Electrolyte levels, particularly magnesium
Drug Interactions
Rabeprazole may interact with other medications, including certain anticoagulants, antifungals, and antiretrovirals. It is important to inform healthcare providers about all medications being taken.
FAQ
How should I take the tablet?
Take rabeprazole orally, usually once daily before a meal. Swallow the tablet whole without crushing or chewing.
What should I avoid while taking?
Avoid alcohol and NSAIDs unless directed by a healthcare provider, as they may increase the risk of gastrointestinal side effects.
What happens if I miss a dose?
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
