Tramadol

Tramadol hydrochloride is an opioid analgesic. It also has noradrenergic and serotonergic properties that may contribute to its analgesic activity. Tramadol is used for moderate to severe pain.

Pronunciation

Tramadol 50mg

Generic Name 藥名	HA Code 藥物代碼	Classification藥物分類
Tramdol 50 mg	TRAM01	DD

Mechanism of Action

Pain relief

Opioid analgesic, Seretonin norepinerphrine reuptake inhibitor

Equivalent doses of opioid analgesics

Analgesic/Route	Dose
Codeine: PO	100 mg
Diamorphine: IM, IV, SC	3 mg
Dihydrocodeine: PO	100 mg
Morphine: PO	10 mg
Morphine: IM, IV, SC	5 mg
Oxycodone: PO	6.6 mg
Tramadol: PO	100 mg

Dosage

Tramadol hydrochloride is given orally, intravenously, or rectally as a suppository.

Oral	Initially 50 mg PRN, then adjust according to response. Maximum 400mg /day
Modify release fomulation	100-150 mg QD PRN, maximum 400 mg.
Moderate to severe acute pain	Initially 100 mg, then 50-100mg q4-6h, maximum 400 mg

Moderate to severe chronic pain :
Oral	50 to 100 mg every 4 to 6 hours. The total oral daily dosage should not exceed 400 mg.
Rectal	100mg up to 4 times daily.

Doses in children

In the UK, tramadol hydrochloride is licensed for the management of moderate to severe pain in children 12 years and older; usual adult doses may be given.

Administration in hepatic or renal impairment

• A dosage interval of 12 hours is recommended in severe hepatic impairment.
• The dosage interval should also be increased to 12 hours in patients with a creatinine clearance of less than 30 mL/min.