Pregabalin
Pronunciation
Pregabalin 150mg
Pregabalin 25mg
Pregabalin 50mg
Introduction
Gabapentin is an anticonvulsant medication:
- Peripheral and central neuropathic pain
- Used as an adjunctive therapy for focal seizures with or without secondary generalization.
- Generalized anxiety disorder
Mechanism of Action
Anticonvulsant medication. It inhibits the alpha 2-delta subunit of voltage-dependent calcium channels.
| Generic Name 藥名 | HA Code 藥物代碼 | Classification藥物分類 |
|---|---|---|
| Pregabalin Capsule 25mg | PREG15 | P1S1S3 |
Dosage
Epilepsy,
By mouth: the initial oral dose is 25 mg twice daily, increased at weekly intervals in steps of 50 mg daily to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days to max. 600 mg daily in 2-3 divided doses.
Neuropathic Pain
| {|class="wikitable" | Oral bioavailability | Gabapentin is absorbed from the intestines by means of an active transport process which is saturable, so the pharmacokinetics of gabapentin are dose-dependent, with diminished bioavailability and delayed peak levels at higher doses.
Food increases the bioavailability by about 10%. |
|---|---|---|
| Onset of action | Gabapentin at a low dose of 100 mg has a Tmax (time to peak levels) of about 1.7 hours, while the Tmax increases to 3 to 4 hours at higher doses. | |
| Metabolism | Gabapentin undergoes little or no metabolism. | |
| Elimination half-life | Gabapentin is eliminated renally in the urine.
The elimination half-life has been reported to be about 5 to 7 hours. Gabapentin is distributed into breast milk. |
|Gabapentin is absorbed from the intestines by means of an active transport process which is saturable, so the pharmacokinetics of gabapentin are dose-dependent, with diminished bioavailability and delayed peak levels at higher doses. Food increases the bioavailability by about 10%. |- !style="text-align: left"| Onset of action |Gabapentin at a low dose of 100 mg has a Tmax (time to peak levels) of about 1.7 hours, while the Tmax increases to 3 to 4 hours at higher doses. |- !style="text-align: left"| Metabolism |Gabapentin undergoes little or no metabolism. |- !style="text-align: left"| Elimination half-life |Gabapentin is eliminated renally in the urine. The elimination half-life has been reported to be about 5 to 7 hours. Gabapentin is distributed into breast milk.
|}
