Trifluoperazine
[[Category: ]] Drug Class: Antipsychotics, typical; Antipsychotic 1st Generation
Trifluoperazine (中文:[[ ]]) is a typical antipsychotic or 1st Generation antipsychotic medication. It is used to treat
- Schizophrenia
- Short-term adjunctive management of severe anxiety
- Severe nausea and vomiting
It helps patient to think more cleaerly, feel less nervous, and take part in everyday life. It can reduce aggressive behavior and the desire to hurt oneself/others. It helps to decrease hallucinations.
Pronunciation
Trifluoperazine 1mg
Drug Names
| Generic Name 藥名 | HA Code 藥物代碼 | Classification藥物分類 |
|---|---|---|
| Trifluoperazine Tab 1 mg | TRIF01 | P1S1S3 |
| Trifluoperazine Tab 5 mg | TRIF02 | P1S1S3 |
Mechanism of Action
Trifluoperazine has central antiadrenergic, antidopaminergic, and minimal anticholinergic effects. It works by blocking postsynaptic mesolimbic dopamine D1 and D2 receptors in the brain, minimizing such symptoms of schizophrenia as hallucinations, delusions and disorganized thought and speech. Antiemetic effects are attributed to dopamine receptor blockade in the medullary chemoreceptor trigger zone. The presumed effectiveness of antipsychotic drugs relied on their ability to block dopamine receptors. This assumption arose from the dopamine hypothesis that maintains that both schizophrenia and bipolar disorder are a result of excessive dopamine activity.
