Metoprolol Tartrate
From SEHK Wiki
Pronunciation
Metoprolol tartrate 100mg
Metoprolol tartrate 75mg
Metoprolol tartrate 50mg
Metoprolol tartrate 37.5mg
Metoprolol tartrate 25mg
Metoprolol succinate 200mg
Metoprolol succinate 100mg
Metoprolol succinate 50mg
Metoprolol succinate 25mg
| Generic Name: | Metoprolol Tartrate, Metoprolol succinate |
|---|---|
| Class: | Cardiovascular Drug |
| Subclass: | Beta blocker |
| Legal Classification: |
Drug Name
| Generic Name 藥物化學名稱 | HA Code 藥物代碼 | Legal Classification 法律藥物分類 | Brand Name |
|---|---|---|---|
| Metoprolol Tartrate Tablet 25mg | LOPRESSOR | ||
| Metoprolol Tartrate Tablet 37.5mg | |||
| Metoprolol Tartrate Tablet 50mg | METO07 | ||
| Metoprolol Tartrate Tablet 75mg | |||
| Metoprolol Tartrate Tablet 100mg | METO06 | ||
| Metoprolol Succinate Tablet 25mg | METO16 | BETALOC ZOK | |
| Metoprolol Succinate Tablet 50mg | METO13 | ||
| Metoprolol Succinate Tablet 100mg | METO10 | ||
| Metoprolol Succinate Tablet 200mg | METO11 |
Mechanism of Action
Metoprolol is a β1-selective (cardio-selective) beta-blocker. It works by blocking the action of epinephrine (adrenaline) on beta-1 receptors in the heart. This slows the heart rate, reduces force of heart contractions, oxygen demand and decreases blood pressure.
Route of Administration
Metoprolol is available for:
- Oral administration as immediate-release and extended-release tablets
- Intravenous injection (given by healthcare providers)
Dosages
- Hypertension
- Immediate-release: Typical starting 50 mg once daily, up to 400 mg/day maximum
- Extended-release: Typical starting 100 mg once daily, up to 400 mg/day maximum
- Heart failure: dosage not specified
- Immediate-release: Typical 25-100 mg twice daily
- Extended-release: Typical 25-200 mg once daily
- Diabetic kidney disease: Dosage not specified, adjust based on patient respnose.
Side Effects
The following definitions of frequencies are used:
Very common ≥ 1/10
Common ≥ 1/100 to < 1/10
Uncommon ≥1/1,000 to <1/100
Rare ≥ 1/10,000 to < 1/1,000
Very rare < 1/10,000
| System Organ Class | Frequency | Adverse reactions |
|---|---|---|
| Nervous system disorders | Common | Dizzinss, Fatigue, Memory problem |
| Uncommon | Depression, Confusion, Insomnia | |
| Rare | Nightmares | |
| Skin disorders | Uncommon | Rash |
| Gastro-intestinal disorders | Common | Diarrhoea |
Pharmacokinetics
- Well absorbed from GI tract
- Extensively metabolized in liver
- Elimination half-life 6-7 hours
- Excreted in urine
