Trazodone

Antidepressant Drug

Drug class: Atypical Antidepressants

Trazodone (TRITTICO)（中文：曲唑酮）

Pronunciation

Trazodone 50mg

Common Strengths of Trazodone

Trazodone are available in the following strengths:

• 50 mg, 75 mg, 100 mg, 150 mg

Drug Trade Names of Trazodone

• Trittico
• Desyrel

Drug Usage

• Major depressive disorder (MDD)
• Off-label uses: Anxiety, insomnia, alcohol dependence

Mechanism of Action

Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). It works by:

• Antagonizing 5-HT_2A receptors
• Inhibiting serotonin reuptake
• Blocking histamine H1 and α1-adrenergic receptors

Route of Administration

Oral

Dosages

• Major depressive disorder (MDD):
  • Initial: 150 mg/day in divided doses
  • Maintenance: 150-400 mg/day
  • Maximum: 400 mg/day (outpatients), 600 mg/day (inpatients)

Trazodone can be used in patients with renal impairment without specific adjustments, careful monitoring and cautious titration are advised to ensure safety and efficacy.