Celecoxib

Introduction

Celecoxib is a nonsteroidal anti-inflammatory drug, an NSAID, selectively inhibit cyclo-oxygenase-2 (COX-2). As an NSAID, celecoxib is an analgesic, anti-inflammatory and antipyretic.

Clinical indications for indomethacin include:

• rheumatoid arthritis
• alkylosing spondylitis
• osteoarthritis
• gouty arthritis
• acute painful shoulder bursitis or tendinitis

It is also be used in menstrual pain, headaches, dental pain, postoperative and postpartum pain.

Mechanism of Action

• Anti-inflammatory agent
• Non-steroidal anti-inflammatory drug (NSAID)
• Highly selective COX-2 inhibitor

Dosage

For osteoarthritis

Oral: 200 mg daily given as a single dose or in 2 divided doses. If necessary a dose of 200 mg twice daily may be used.

For rheumatoid arthritis

Oral: 100 to 200 mg given twice daily.