Rivastigmine
Pronunciation
Rivastigmine 1.5mg (EXELON 1.5mg)
Rivastigmine 3mg (EXELON 3mg)
Rivastigmine 4.5mg (EXELON 4.5mg)
Introduction
Rivastigmine, is a reversible acetylcholinesterase inhibitor. Rivastigmine is selective for the CNS and is used for the treatment of mild to moderate dementia associated with Parkinson’s disease.
Mechanism of Action
Acetylcholinesterase inhibiting drug
| Generic Name 藥名 | HA Code 藥物代碼 | Classification藥物分類 |
|---|---|---|
| Rivastigmine Cap 1.5 mg | RIVA01 | P1S1S3 |
| Rivastigmine Cap 3 mg | RIVA02 | P1S1S3 |
| Rivastigmine Cap 6 mg | RIVA04 | P1S1S3 |
Dosage
The drug can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects, which typically include nausea and vomiting.
By Oral: initially 1.5 mg twice daily, increased in steps of 1.5 mg twice daily at intervals of at least 2 weeks according to response and tolerance. Usual range 3-6 mg twice daily. Maximum 6 mg twice daily. If treatment interrupted for more than several days, treatment should be retitrated from 1.5 mg twice daily.
Transdermal patches delivering 4.6, 9.5, or 13.3 mg of rivastigmine over 24 hours are also available for once-daily application.
Transdermal application: initially apply 4.6 mg/24 hours patch to clean, dry, non-hairy, non-irritated skin on back, upper arm, or chest, removing after 24 hours. It should not be applied to the abdomen or thigh due to decreased bioavailability. Re-application to the same site should be avoided for 14 days. Only one patch should be applied at a time.
If well tolerated, increase to 9.5 mg/24 hours patch daily.
