Dexamethasone

Pronunciation

Dexamethasone 0.5mg

Introduction

Dexamethasone is a steroid with anti-inflammatory and immunosuppressant effects. It is used to treat a wide range of inflammatory and autoimmune conditions.

Indications include:

• Inflammatory bowel disease
• Asthma
• Croup in children
• dermatitis
• Rheumatoid arthritis
• Cerebral oedema associated with malignancy
• Counteract nausea and vomiting effects of cancer chemotherapy
• Administered before antibiotics in cases of baceterial meningitis. It reduces the inflammatory response, thus reducing hearing loss and neurological damage.
• High-attitude cerebral edema (HACE) and high-attitude pulmonary edema (HAPE), help climbers to cope with complications of high-attitude sickness

Equivalent anti-inflammatory doses of steroids

Prednisolone 5 mg is equivalent to	Betamethasone 750 micrograms
	dexamethasone 750 micrograms
	hydrocortisone 20 mg
	methylprednisolone 4 mg
	triamcinolone 4 mg

Mechanism of Action

Immunosuppression agent, Steroid replacement agent, Anti-inflammatory agent

Generic Name 藥名	HA Code 藥物代碼	Classification藥物分類
Dexamethasone Tablet 0.5 mg	DEXA01	P1S1S3
Dexamethasone Tablet 4 mg	DEXA19	P1S1S3
Dexamethasone 0.1% + Chloramphenicol 0.5% Eye Drops 5ml	DEXA16	P1S1S3
Dexamethasone 0.1% + Neomycin 0.5% Eye Drops 10ml	DEXA04	P1S1S3

Dosage

Dosages of steroids vary widely in different diseases and in different patients. When long-term steroid therapy is used in some chronic diseases, the adverse effects of treatment may be great. To minimize side-effects the maintenance dose should be kept as low as possible. Steroids are used both topically (by rectum or eye) and systemically (by mouth or intravenously). Whenever possible local treatment with creams, intra-articular injections, inhalations, eye-drops or enemas should be used in preference to systemic treatment. The suppressive action of a steroid on cortisol secretion is least when it is given as a single dose in the morning.