Introduction
Topiramate is a medication used to treat epilepsy and prevent migraines. For epilepsy this includes treatment for generalized or focal seizures. It is also used as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome.
| Generic Name 藥名
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HA Code 藥物代碼
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Classification藥物分類
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| Topiramate Tablet 25 mg
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TOPI01
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P1S1S3
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| Topiramate Tablet 50 mg
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TOPI01
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P1S1S3
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| Topiramate Tablet 100 mg
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TOPI03
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P1S1S3
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Mechanism of Action
Anticonvulsant medication. It inhibits the sodium channels, calcium channels, GABA-A receptors, and carbonic anhydrase isoenzymes, contributing to the antiseizure effects.
Dosage
| For both adjunctive and monotherapy of epilepsy
|
By mouth
ADULT:
- Initial dose of 25 to 50 mg at night for 1 week; then
- Increased by increments of 25 or 50 mg at intervals of 1 to 2 weeks until the effective dose is reached.
- Daily doses of more than 25 mg should be taken in 2 divided doses.
- The usual daily dose for adjunctive therapy is 200 to 400 mg
- When used as monotherapy, usual doses range from 100 mg daily to a maximum of 500 mg daily.
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For monotherapy, CHILD 6 – 17 years:
- Initially 0.5 -1 mg/kg at night for the first week,
- Increased thereafter by 0.5 – 1 mg/kg every 1 or 2 weeks, to an initial target dose of 100 mg (about 2 mg/kg) daily in 2 divided doses.
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As adjunctive therapy, CHILD form 2 years of age:
- 1 – 3 mg/kg once daily (maximum 25 mg). This is given as a single dose at night for 1 week, then
- Increased by 1 to 3 mg/kg every 1 or 2 weeks until the effective dose is reached.
- About 5 to 9 mg/kg daily is usually required.
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| Migraine prophylaxis
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By mouth
ADULT:
- Initially 25 mg once daily at night for 1 week, then
- Increased in steps of 25 mg every 1 week.
- Usual dose 50 – 100 mg daily in 2 divided doses
- Maximum 200 mg per day
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