Edoxaban

Anticoagulant Drug

Drug class: Direct Factor Xa inhibitor

Edoxaban (LIXIANA)（中文：依度沙班）

Common Strengths of Edoxaban

Edoxaban are available in the following strengths: 15 mg, 30 mg, 60 mg tablets

Drug Trade Names of Edoxaban

Lixiana

Drug Usage

• Reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
• Treatment of deep vein thrombosis (DVT) and pulmonary embolism
• Reduce risk of recurrent DVT and PE

Mechanism of Action

Selectively inhibits factor Xa, preventing the formation of blood clots.

Route of Administration

Oral

Dosages

• 60 mg once daily
• No specific dosages for hypertension, heart failure, or diabetic kidney disease

Renal dosing based on eGFR:

• Mild impairment (CrCl > 50 mL/min): The recommended dose is 60 mg once daily
• Moderate renal impairment (CrCl 30-50 mL/min): The dose should be reduced to 30 mg once daily
• Severe renal impairment (CrCl 15-29 mL/min): The recommended dose is 30 mg once daily, but should be used with caution
• End-stage renal disease (CrCl < 15 mL/min) or on dialysis: Not recommended

Side Effects

Frequency	Adverse reactions
Common	Easy bruising
	Anemia
Uncommon	Abnormal liver function tests
	Allergic reactions

Pharmacokinetics

• Metabolism
  • Minimal hepatic metabolism
• Elimination
  • 50% renal excretion
• Drug Onset
  • 1 - 2 hours after oral dosing
• Duration
  • 24 hours (once-daily dosing)

Drug Precautions

Pregnancy

Not recommended

Breastfeeding

Not recommended

Renal Impairment

Dose adjustment required (see renal dosing)

Monitoring Requirements

• Renal function test
• Signs and symptoms of bleeding:
  • Unexpected bleeding or bleeding that lasts a long time
  • Unusual bruising, nosebleeds, bleeding gums
  • Pink/brown urine, red/black stools
  • Coughing up blood or blood clots
  • Vomiting blood or vomit that looks like coffee grounds

Drug Interactions

Anticoagulants, NSAIDs, antiplatelet drugs

Caution

Use with caution in patients at risk of bleeding, or taking concomitant drugs that increase risk of bleeding.

FAQ

How Should I Take the Tablet?

Take with or without food, at the same time each day. It can be crushed and mixed with water if unable to be swallowed whole.

What Should I Avoid While Taking?

Activities that increase the risk of bleeding or injury

What Happens if I Miss a Dose?

Take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next scheduled dose