Apixaban

Anticoagulant Drug

Drug class: Direct Factor Xa inhibitor

Apixaban (ELIQUIS)（中文：阿哌沙班）

Common Strengths of Apixaban Tablet

Apixaban Tablet are available in the following strengths:

• 2.5 mg and 5 mg tablets

Drug Trade Names of Apixaban Tablet

Eliquis

Drug Usage

• Reduce risk of stroke and systemic embolism in nonvalvular atrial fibrillation
• Prevent deep vein thrombosis (DVT) and pulmonary embolism (PE) after hip or knee replacement surgery
• Reduce risk of recurrent DVT and PE

Mechanism of Action

Direct Factor Xa inhibitors is a selective clotting factor Xa (FXa) inhibitor, preventing the formation of blood clots

Route of Administration

Oral

Dosages

• Nonvalvular atrial fibrillation: 5 mg orally twice daily
• DVT/PE prevention after surgery: 2.5 mg orally twice daily
• DVT/PE treatment: 10 mg orally twice daily for 7 days, then 5 mg twice daily
• Reduce risk of recurrent DVT/PE: 2.5 mg orally twice daily

Side Effects

Frequency	Adverse reactions
Common	Easy bruising
	Anemia
	Nausea
Uncommon	Thrombocytopenia
	Allergic reactions
	Hypotension
	Intracranial hemorrhage

Pharmacokinetics

• Absorption
  • It is rapidly absorbed, with maximum concentration occurring 3-4 hours after oral administration
• Metabolism and Elimination
  • Apixaban is eliminated through multiple pathways, including metabolism, biliary excretion, and direct intestinal excretion
• half-life of approximately
  • 12 hours

Drug Precautions

Pregnancy

Not recommended

Breastfeeding

Not recommended

Monitoring Requirements

Signs and symptoms of bleeding:

• Unexpected bleeding or bleeding that lasts a long time
• Unusual bruising, nosebleeds, bleeding gums
• Pink/brown urine, red/black stools
• Coughing up blood or blood clots
• Vomiting blood or vomit that looks like coffee grounds

Drug Interactions

Interacts with other blood thinners, NSAID, antidepressants, and certain herbal products like St. Johin's wort

Caution

Use with caution in patients at risk of bleeding, or taking concomitant drugs that increase risk of bleeding.

FAQ

How Should I Take the Tablet?

Take with or without food, usually twice daily

What Should I Avoid While Taking?

Avoid activities with a high risk of injury or bleeding

What Happens if I Miss a Dose?

Take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next scheduled dose