Etodolac
| Generic Name 藥名 | HA Code 藥物代碼 | Classification藥物分類 |
|---|---|---|
| Etodolac Capsule 200mg | P1S1S3 |
Mechanism of Action
Anti-inflammatory agent, Non-steroidal anti-inflammatory drug (NSAID) selective COX-2 inhibitor
Dosage
In the treatment of rheumatoid arthritis and osteoarthritis:
|Oral: initially 600 to 1000 mg daily in divided doses adjusted to response to a maintenance dose of 300 to 600 mg daily. Modified-release preparations are available for once-daily use in stable conditions.
|For treatment of acute pain:
|Oral: 200 to 400 mg every 6 to 8 hours, to a maximum of 1 g daily.
|Piroxicam has been given in similar doses as a rectal suppository or on a short-term basis by intramuscular injection. Piroxicam is one of the few NSAIDs that can be given parenteral routes.
|Administration in children
|Etodolac has been used in children with juvenile idiopathic arthritis. The following doses, given according to body-weight, are recommended for children aged 6 years and over:
- 20 to 30 kg: 400 mg once daily
- 31 to 45 kg: 600 mg once daily
- 46 to 60 kg: 800 mg once daily
- Over 60 kg: 1 g once daily
Side Effects
As with other NSAIDs the principal side effects include:
- Digestive complaints like nausea, heartburn, diarrhoea and bleeds or ulceration of the stomach
- Headache, dizziness, depression, drowsiness, insomnia
- Hearing disturbances such as tinnitus
- High blood pressure, oedema
- Skin reactions (including, albeit rarely, Stevens-Johnson syndrome and toxic epidermal necrolysis)
- And rarely, kidney failure, pancreatitis and liver damage
Etodolac is a preferential inhibitor of cyclo-oxygenase-2 (COX-2) and consequently it has less gastric toxicity than the non-selective NSAIDs such as naproxen.
