Ibuprofen
| Generic Name 藥名 | HA Code 藥物代碼 | Classification藥物分類 |
|---|---|---|
| Ibuprofen Tablet 200 mg | Part 1 Poison | |
| Ibuprofen Tablet 400 mg | Part 1 Poison |
Mechanism of Action
Non-opioid Analgesic (NSAID) Anti-inflammatory agent Nonselective COX inhibitor
Dosage
Usual oral dose for painful conditions:
Oral: 400 to 600 mg every 4 to 6 hours to a maximum of 2.4 g daily.
Intravenous infusion: 400 to 800 mg every 6 hours as necessary.
Topical: applied as a 5% cream, foam, gel or spray solution.
The recommended dose for fever reduction:
Oral: 200 to 400 mg every 4 to 6 hours to a maximum of 1.2 g daily.
Administration in children Given according to age for the treatment of pain, inflammation of soft-tissue injuries or fever in children:
- 1 to 2 months: 5 mg/kg 3 or 4 times daily
- 3 to 5 months: 50 mg 3 times daily
- 6 to 11 months: 50 mg 3 or 4 times daily
- 1 to 3 years: 100 mg 3 times daily
- 4 to 6 years: 150 mg 3 times daily
- 7 to 9 years: 200 mg 3 times daily
- 10 to 11 years: 300 mg 3 times daily
- 12 to 17 years: initially 300 to 400 mg 3 or 4 times daily, if necessary, to a maximum of 2.4 g daily.
- For more severe symptoms in children aged between 3 months and 11 years, a dose of 30 mg/kg (maximum 2.4 g) daily in 3 or divided doses may be given.
Side Effects
As for NSAIDs in general.
Common side effects include heartburn, nausea, dyspepsia, diarrhoea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure.
It increases the risk of heart attack, stroke, kidney failure and liver failure.
Ibuprofen can also worsen asthma.
Cardiovascular risk Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk in 2015.
