Ertugliflozin

Antidiabetic Drug

Drug class: Sodium-glucose co-transporter 2 (SGLT2) inhibitor

Ertugliflozin (STEGLATRO)（中文：埃格列淨）

Common Strengths of Ertugliflozin Tablet

Ertugliflozin tablets are available in the following strengths:

• 5 mg and 15 mg tablets

Drug Trade Names of Ertugliflozin Tablet

Steglatro

It is also sold under various brand names when combined with other antidiabetic medications, such as:

• STEGLUJAN TABLET 5MG/100MG: Ergugliflozin 5mg + Sitagliptin 100mg

Drug Usage

Treatment of type 2 diabetes mellitus

Mechanism of Action

Inhibits sodium-glucose co-transporter 2 (SGLT2) in the proximal renal tubules, reducing glucose reabsorption and increasing urinary glucose excretion

Route of Administration

Oral

Dosages

• Type 2 diabetes: Starting dose 5 mg once daily, can be increased to 15 mg once daily
• Not specifically indicated for hypertension, heart failure, or diabetic kidney disease

Renal dose based on eGFR:

• eGFR ≥60 mL/min/1.73 m²: No dose adjustment required
• eGFR 30 to <60 mL/min/1.73 m²: Not recommended to initiate therapy
• eGFR <30 mL/min/1.73 m²: Contraindicated

Side Effects

Frequency	Adverse reactions
Common	Urinary tract infections
	Male and female genital mycotic infections
	Increased urination
Uncommon	Volume depletion
	Diabetic ketoacidosis (DKA) - a condition where blood becomes too acidic

Pharmacokinetics

• Absorption
  • Rapidly absorbed, peak plasma concentrations within 1 hour
• Metabolism
  • Primary metabolism via UGT1A9 and UGT2B7-mediated O-glucuronidation
• Elimination
  • Half-life approximately 17 hours
• Drug duration of action
  • 24 hours

Drug Precautions

Pregnancy

Not recommended

Breastfeeding

Not recommended

Children and Elderly

Not recommended for children under 18 years. No dose adjustment is required for elderly patients

Renal Impairment

Use with caution, dosage adjustments based on eGFR

Monitoring Requirements

Renal function, volume status, signs of ketoacidosis

Drug Interaction

May increase the risk of hypoglycemia when used with insulin or insulin secretagogues

FAQ

How Should I Take the Tablet?

Take once daily in the morning, with or without food

What Should I Avoid While Taking?

Avoid excessive alcohol consumption and dehydration

What Happens if I Miss a Dose?

Take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.