Sulpiride: Difference between revisions
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[[Category: Drugs]][[Category: | [[Category: Drugs]][[Category: Typical Antipsychotic ]] | ||
[[:Category: Antipsychotic Drug | '''Antipsychotic Drug''']] | |||
[[ | |||
'''Drug class: [[:Category: Typical Antipsychotic | Typical Antipsychotic]] | |||
[[ | |||
== | '''Sulpiride (DOGMATIL)'''（中文：[[舒必利]]） | ||
==Common Strengths of Sulpiride Tablet== | |||
Sulpiride are available in the following strengths: | |||
*50 mg, 200 mg, 400 mg tablets/capsules | |||
== | ==Drug Trade Names of Sulpiride Tablet== | ||
Dogmatil | |||
== | ==Drug Usage== | ||
Treatment of acute and chronic schizophrenia | |||
==Mechanism of Action== | |||
Selective dopamine D<sub>2</sub> and D<sub>3</sub> receptor antagonist | |||
==Route of Administration== | |||
Oral | |||
==Dosages== | |||
*Adults: 400 - 1200 mg daily, divided into 2 doses | |||
==Side Effects== | ==Side Effects== | ||
{| class="wikitable" | |||
{| class = "wikitable" | !style="text-align: left"| Frequency | ||
!style="text-align: left"| | !Adverse reactions | ||
|- | |- | ||
| rowspan="13" | '''Common | |||
| | | Dizziness | ||
|- | |||
| Headache | |||
|- | |||
- | | Extrapyramidal side effects such as tremor, dystonia, akathisia, and parkinsonism | ||
|- | |||
- | | Drowsiness | ||
|- | |||
- | | Insomnia | ||
|- | |||
- | | Weight gain or loss | ||
|- | |||
- | | Elevated levels of prolactin which can lead to sexual dysfunction, galactorrhea, amenorrhea, and gynecomastia | ||
|- | |||
- | | Nausea | ||
|- | |||
| Vomiting | |||
|- | |||
| Nasal congestion | |||
|- | |||
| Anticholinergic effects such as dry mouth, constipation, and blurred vision | |||
|- | |||
| Impaired concentration | |||
|- | |||
| Increased skin sensitivity to sunlight | |||
|- | |||
| rowspan="8" | '''Serious | |||
| Tardive dyskinesia: A potentially irreversible condition characterized by repetitive, involuntary movements of the face and tongue | |||
|- | |||
| Neuroleptic Malignant Syndrome (NMS): A rare but life-threatening condition marked by muscle stiffness, high fever, confusion, fast heartbeat, and sweating | |||
|- | |- | ||
| Arrhythmias, low blood pressure, and in rare cases, cardiac arrest | |||
|- | |- | ||
| Severe allergic reactions: Anaphylactic shock, rash, and labored breathing | |||
| | |||
|- | |- | ||
| Oculogyric crisis: Spastic movements that fix the eyes in an upward position | |||
| | |||
|- | |- | ||
| Venous thromboembolism | |||
| | |||
|- | |- | ||
| Increased liver enzymes: Indicating potential liver dysfunction | |||
| | |||
|- | |- | ||
| Aspiration pneumonia | |||
|} | |} | ||
==Pharmacokinetics== | ==Pharmacokinetics== | ||
*Time to peak plasma concentration: between 3 to 6 hours after dosing | |||
*Sulpiride undergoes minimal metabolism in the body. About 95% excreted unchanged in urine. | |||
==Drug Precautions== | |||
'''Pregnancy | |||
Use only if benefits outweigh risks. Risk of extrapyramidal/withdrawal symptoms in newborns exposed in 3rd trimester. | |||
'''Breastfeeding | |||
Excreted in breast milk. | |||
It is | '''Children and Elderly | ||
*Children: Not recommended for children under 14 years | |||
*Elderly: Lower starting doses recommended | |||
'''Renal Impairment | |||
Use with caution, dose adjustment may be needed | |||
'''Monitoring Requirements | |||
*Extrapyramidal symptoms | |||
*Monitor for increased sedation when sulpiride is used with other CNS depressants | |||
*Regular ECG in patients at risk of QT prolongation | |||
*Monitor potassium levels when sulpiride is used with diuretics or stimulant laxatives. | |||
*Complete blood count | |||
*Liver function tests | |||
*Blood pressure | |||
*Eye examinations (long-term use) | |||
'''Drug Interactions | |||
*Increased sedation with CNS depressants: | |||
**Sedatives and Sleeping Pills: Drugs like nitrazepam, diazepam, and temazepam can increase the sedative effects of sulpiride, leading to enhanced drowsiness and sedation | |||
**Narcotics and Strong Pain Relievers: Medications such as codeine phosphate, morphine, and dihydrocodeine can also amplify CNS depression when taken with sulpiride | |||
*Increased risk of arrhythmias with drugs that prolong QT interval | |||
**Antiarrhythmics: Drugs such as disopyramide, amiodarone, sotalol, and quinidine can increase the risk of cardiac arrhythmias when used with sulpiride | |||
**Antihypertensives and Heart Medications: Clonidine, verapamil, diltiazem, and digitalis may have enhanced effects, potentially leading to hypotension and other cardiovascular issues | |||
**Diuretics and Laxatives: These can lower potassium levels, increasing the risk of cardiac arrhythmias when taken with sulpiride | |||
*Levodopa and Ropinirole: These drugs can antagonize the effects of sulpiride, and their combination should be avoided | |||
*Lithium (increased extrapyramidal effects risk) | |||
*Sucralfate and Magnesium Hydroxide (antacid) can decrease the absorption of sulpiride, reducing its effectiveness. It is recommended to administer sulpiride two hours before these medications | |||
==FAQ== | |||
'''How Should I Take the Tablet? | |||
It can be taken with or without food. | |||
'''What Should I Avoid While Taking? | |||
Avoid alcohol and activities requiring mental alertness until you know how trifluoperazine affects you. | |||
'''What Happens if I Miss a Dose? | |||
Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not double doses. | |||
Latest revision as of 23:22, 31 July 2024
Drug class: Typical Antipsychotic
Sulpiride (DOGMATIL)（中文：舒必利）
Common Strengths of Sulpiride Tablet[edit]
Sulpiride are available in the following strengths:
- 50 mg, 200 mg, 400 mg tablets/capsules
Drug Trade Names of Sulpiride Tablet[edit]
Dogmatil
Drug Usage[edit]
Treatment of acute and chronic schizophrenia
Mechanism of Action[edit]
Selective dopamine D2 and D3 receptor antagonist
Route of Administration[edit]
Oral
Dosages[edit]
- Adults: 400 - 1200 mg daily, divided into 2 doses
Side Effects[edit]
| Frequency | Adverse reactions |
|---|---|
| Common | Dizziness |
| Headache | |
| Extrapyramidal side effects such as tremor, dystonia, akathisia, and parkinsonism | |
| Drowsiness | |
| Insomnia | |
| Weight gain or loss | |
| Elevated levels of prolactin which can lead to sexual dysfunction, galactorrhea, amenorrhea, and gynecomastia | |
| Nausea | |
| Vomiting | |
| Nasal congestion | |
| Anticholinergic effects such as dry mouth, constipation, and blurred vision | |
| Impaired concentration | |
| Increased skin sensitivity to sunlight | |
| Serious | Tardive dyskinesia: A potentially irreversible condition characterized by repetitive, involuntary movements of the face and tongue |
| Neuroleptic Malignant Syndrome (NMS): A rare but life-threatening condition marked by muscle stiffness, high fever, confusion, fast heartbeat, and sweating | |
| Arrhythmias, low blood pressure, and in rare cases, cardiac arrest | |
| Severe allergic reactions: Anaphylactic shock, rash, and labored breathing | |
| Oculogyric crisis: Spastic movements that fix the eyes in an upward position | |
| Venous thromboembolism | |
| Increased liver enzymes: Indicating potential liver dysfunction | |
| Aspiration pneumonia |
Pharmacokinetics[edit]
- Time to peak plasma concentration: between 3 to 6 hours after dosing
- Sulpiride undergoes minimal metabolism in the body. About 95% excreted unchanged in urine.
Drug Precautions[edit]
Pregnancy
Use only if benefits outweigh risks. Risk of extrapyramidal/withdrawal symptoms in newborns exposed in 3rd trimester.
Breastfeeding
Excreted in breast milk.
Children and Elderly
- Children: Not recommended for children under 14 years
- Elderly: Lower starting doses recommended
Renal Impairment
Use with caution, dose adjustment may be needed
Monitoring Requirements
- Extrapyramidal symptoms
- Monitor for increased sedation when sulpiride is used with other CNS depressants
- Regular ECG in patients at risk of QT prolongation
- Monitor potassium levels when sulpiride is used with diuretics or stimulant laxatives.
- Complete blood count
- Liver function tests
- Blood pressure
- Eye examinations (long-term use)
Drug Interactions
- Increased sedation with CNS depressants:
- Sedatives and Sleeping Pills: Drugs like nitrazepam, diazepam, and temazepam can increase the sedative effects of sulpiride, leading to enhanced drowsiness and sedation
- Narcotics and Strong Pain Relievers: Medications such as codeine phosphate, morphine, and dihydrocodeine can also amplify CNS depression when taken with sulpiride
- Increased risk of arrhythmias with drugs that prolong QT interval
- Antiarrhythmics: Drugs such as disopyramide, amiodarone, sotalol, and quinidine can increase the risk of cardiac arrhythmias when used with sulpiride
- Antihypertensives and Heart Medications: Clonidine, verapamil, diltiazem, and digitalis may have enhanced effects, potentially leading to hypotension and other cardiovascular issues
- Diuretics and Laxatives: These can lower potassium levels, increasing the risk of cardiac arrhythmias when taken with sulpiride
- Levodopa and Ropinirole: These drugs can antagonize the effects of sulpiride, and their combination should be avoided
- Lithium (increased extrapyramidal effects risk)
- Sucralfate and Magnesium Hydroxide (antacid) can decrease the absorption of sulpiride, reducing its effectiveness. It is recommended to administer sulpiride two hours before these medications
FAQ[edit]
How Should I Take the Tablet?
It can be taken with or without food.
What Should I Avoid While Taking?
Avoid alcohol and activities requiring mental alertness until you know how trifluoperazine affects you.
What Happens if I Miss a Dose?
Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not double doses.
