Duloxetine

Antidepressant Drug

Drug class: Serotonin-Norepinephrine Reuptake Inhibitor

Duloxetine (CYMBALTA)（中文：度洛西汀）

Common Strengths of Duloxetine

Duloxetine are available in the following strengths:

• 30 mg
• 60 mg

Drug Trade Names of Duloxetine

Cymbalta

Drug Usage

Duloxetine is used to treat:

• Major depressive disorder (MDD) in adults
• Generalized anxiety disorder (GAD) in adults and children 7 years and older
• Fibromyalgia in adults and children 13 years and older
• Diabetic peripheral neuropathy in adults
• Chronic musculoskeletal pain in adults

Mechanism of Action

Duloxetine is a selective serotonin and norepinephrine reuptake inibitor (SNRI). It works by increasing the levels of serotonin and norepinephrine in the brain, which helps maintain mental balance and inhibit pain signals.

Route of Administration

Oral (delayed-release capsules)

Dosages

• Depression: 40-60 mg/day, up to 120 mg/day
• Anxiety: 60 mg/day, up to 120 mg/day
• Diabetic neuropathy: 60 mg/day
• Fibromyalgia: 30-60 mg/day

Side Effects

Frequency	Adverse reactions
Common	Nausea: Stick to simple meals and avoid rich or spicy food
	Dry mouth: Chew sugar-free gum or sweets
	Constipation: Increase fiber intake and drink plenty of water
	Excessive Sweating: Wear loose clothing and use a fan if needed
	Insomnia: Take in morning
	Blurred vision
	Diarrhea (in children)
	Loss of appetite
Serious	Liver damage: Symptoms may include itching, upper right abdominal pain, dark urine, yellowing of skin/eyes
	Serotonin syndrome: Symptoms can include agitation,