Pantoprazole (PANTOLOC)

Gastrointestinal Drug

Drug class: Proton Pump Inhibitors (PPI)

Pantoprazole (中文: 泮托拉唑)

Drug Class

Proton Pump Inhibitor (PPI)

Common Strengths of Pantoprazole tablet

Pantoprazole tablet are available in the following strengths:

• 20 mg delayed-release oral tablets

• 40 mg delayed-release oral tablets

• Intravenous (IV) formulation for injection

Drug Trade Name of Pantoprazole tablet

PANTOLOC

Drug Usage

Pantoprazole is used for:

Healing of erosive esophagitis (EE)

Management of erosive esophagitis due to GERD

Treatment of gastroesophageal reflux disease (GERD)

Prevention of gastric damage in patients taking NSAIDs

Mechanism of Action

Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking gastric acid production in the stomach

Route of Administration

Oral and intravenously (injection)

Dosages

For adults and children aged 12 years and older, the typical dosage is:

GERD: 40 mg once daily for up to 8 weeks

Renal Dose Adjustments

There are no specific renal dose adjustments recommended based on estimated glomerular filtration rate (eGFR) for pantoprazole; however, caution should be exercised in severe renal impairment.

Side Effects

Frequency	Adverse reactions
Common Side Effects
	Diarrhea
	Abdominal pain
	Nausea
	Vomiting
	Flatulence
Serious Side Effects
	Bone fractures
	Clostridium difficile infection
	Anaphylaxis
	Vitamin B12 deficiency

Pharmacokinetics

Onset Time: Effects can be observed within 2 to 3 hours after oral administration.

Duration of Action: The acid-suppressive effect lasts approximately 24 hours.

Drug Precautions

Pregnancy: Pantoprazole should be used during pregnancy only if clearly needed, as its safety has not been established.

Breastfeeding: It is not known whether pantoprazole passes into breast milk; caution is advised.

Children and Elderly: Use in children over 5 years is generally safe; elderly patients may require monitoring due to the potential increased risk of side effects.

Monitoring Items

Regular monitoring of magnesium and vitamin B12 levels

Drug Interactions

Drug Interactions: Pantoprazole may interact with medications such as warfarin, methotrexate, and certain antifungals. It can affect the absorption of drugs that require an acidic environment.

FAQ

How should I take the tablet?

Take pantoprazole before meals, swallowing the tablet whole without crushing or chewing

What should I avoid while taking?

Avoid highly acidic foods and grapefruit

What happens if I miss a dose?

Take as soon as remembered unless close to next dose; do not double up on doses