Amlodipine

Amlodipine(中文:氨氯地平) is a dihydropyridine calcium-channel blocker. It is used in the management of hypertension and angina.

Pronunciation

Amlodipine 10mg

Amlodipine 5mg

	HA Code:
Generic Name :
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Legal Classification:
	Amlodipine	NORVASC	Cardiovascular Drug	Calcium-channel Blocker, CCB	P1S1S3

Drug Names

Generic Name 藥物化學名稱	HA Code 藥物代碼	Legal Classification法律藥物分類	Brand Name 品牌名稱
Amlodipine Besylate Tablet 5mg	AMLO01	P1S1S3	NORVASC
Amlodipine Besylate Tablet 10mg	AMLO02	P1S1S3	NORVASC

Mechanism of Action

Amlodipine relaxes and widens blood vessels. It does this by blocking calcium going into muscles in the heart and blood vessels. Muscles need calcium to contract, so when you block the calcium, it makes the muscle cells relax. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. In angina, amlodipine works by improving the blood and oxygen supply to your heart. Angina is chest pain that comes on when not enough blood gets to the muscles of the heart. This usually happens because the arteries going to the heart become hardened and narrowed.

Route of Administration

Amlodipine is given orally as the besylate, but doses are expressed in terms of the base. Amlodipine besylate 6.9 mg is equivalent to about 5 mg of amlodipine.

Dosage

Agina

• BY MOUTH
• Adult: initially 5 mg once daily; maximum 10 mg per day

Hypertension

• BY MOUTH
• Adult: initially 5 mg once daily; maximum 10 mg per day

Elderly

Amlodipine used at similar doses in elderly or younger patients.

Hepatic impairment

May need dose reduction – half-life prolonged