Nortriptyline

Antidepressant Drug

Drug class: Tricyclic Antiperessant Drug

Nortriptyline（中文：去甲替林）

Common Strengths of Nortriptyline

Nortriptyline are available in the following strengths:

• 10 mg, 25 mg, 50 mg, 75 mg capsules

Drug Trade Names of Nortriptyline

• Pamelor
• Aventyl

Drug Usage

• Treatment of depression
• Off-Label Uses: Neuropathic pain, irritable bowel syndrome (IBS), migraine prevention, and panic disorder

Mechanism of Action

• Inhibits reuptake of serotonin and norepinephrine at neuronal cell membranes
• More selective reuptake inhibition for norepinephrine

Route of Administration

Oral

Dosages

• Adults: 25 mg orally, taken 3 to 4 times per day. Maximum dose up to 150 mg/day.
• Elderly: 30 to 50 mg/day in divided doses or as a single daily dose.

Side Effects

Frequency	Adverse reactions
Common	Drowsiness/sedation
	Dizziness
	Dry mouth
	Blurred vision
	Constipation
	Increased blood pressure
	Numbness or tingling in hands/feet
	Nausea, vomiting, loss of appetite
	Rash, itching
	Breast swelling (in men or women)
Serious	Suicidal thoughts and behaviors (especially in young adults)
	Serotonin syndrome (confusion, fast heart rate, agitation)
	Agranulocytosis (severe reduction in white blood cells)
	Seizures
	Angle-closure glaucoma (eye pain, blurred vision)
	Severe allergic reactions (rash, hives, swelling, trouble breathing)
	Severe skin reactions (blistering, peeling skin)
	Fast, irregular heartbeat
	Painful or difficult urination
	Jaundice (yellowing of skin or eyes)