Pramipexole

Antiparkinsonian Drug

Drug class: Dopaminergic Antiparkinsonian Agent

Pramipexole (MIRAPEX)（中文：普拉克索）

Common Strengths of Pramipexole

• Immediate-release tablets: 0.125 mg, 0.25 mg, 0.5 mg, 0.75 mg, 1 mg, 1.5 mg.
• Extended-release tablets: 0.375 mg, 0.75 mg, 1.5 mg, 2.25 mg, 3 mg, 3.75 mg, 4.5 mg.

Drug Trad Names

• Mirapex, Mirapex ER

Drug Usage

Pramipexole is indicated for:

• Parkinson's Disease: Alleviates symptoms like tremors and rigidity.
• Restless Legs Syndrome: Reduces discomfort and the urge to move the legs.

Mechanism of Action

Pramipexole selectively Stimulates dopamine D2 and D3 receptors in the brain, which helps restore the balance of dopamine levels associated with motor control and movement.

Route of Administration

• Oral

Dosage

• Parkinson's Disease: Start at 0.125 mg three times daily, titrate up to 4.5 mg/day.
• RLS: Start at 0.125 mg once daily, titrate up to 0.5 mg/day.

Side Effects

Frequency	Adverse reactions
Common Side Effects	Drowsiness,dizziness, dry mouth, nausea, constipation, hallucinations.
Serious Side Effects	Sudden sleep onset during activites, increased risk of heart failure in some patients.