Rotigotine

Antiparkinsonian Drug

Drug class: Dopaminergic Antiparkinsonian Agent

Rotigotine (NEUPRO)（中文：羅替戈汀）

Common Strengths

Rotigotine is available in a transdermal patch form, which provides a continuous release of the medication over 24 hours. It is available in several strengths:

• 1 mg/24 hr
• 2 mg/24 hr
• 3 mg/24 hr
• 4 mg/24 hr
• 6 mg/24 hr
• 8 mg/24 hr

Drug Trade Names

• Neupro

Drug Usage

• Rotigotine is used for:
  • Treating Parkinson's disease (both early and advanced stages)
  • Managing moderate-to-severe primary Restless Legs Syndrome (RLS)

Mechanism of Action

Rotigotine acts as an agonist for dopamine receptors (D1, D2, D3) in the brain, which helps restore balance of dopamine, a neurotransmitter that is deficient in Parkinson's disease. It also interacts with adrenergic and serotonergic receptors, contributing to its therapeutic effects.

Route of Administration

Rotigotine is administered transdermally via a patch applied to the skin once daily.

Dosages

• Parkinson's Disease: Start at 2 mg/24 hr; may increase to a maximum of 8 mg/24 hr.
• RLS: Start at 1 mg/24 hr; maximum of 3 mg/24 hr.