Pantoprazole (PANTOLOC)
Drug class: Proton Pump Inhibitors (PPI)
Pantoprazole (中文: 泮托拉唑)
Drug Class
Proton Pump Inhibitor (PPI)
Common Strengths of Pantoprazole tablet
Pantoprazole tablet are available in the following strengths:
- 20 mg delayed-release oral tablets
- 40 mg delayed-release oral tablets
- Intravenous (IV) formulation for injection
Drug Trade Name of Pantoprazole tablet
PANTOLOC
Drug Usage
Pantoprazole is used for:
Healing of erosive esophagitis (EE)
Management of erosive esophagitis due to GERD
Treatment of gastroesophageal reflux disease (GERD)
Prevention of gastric damage in patients taking NSAIDs
Mechanism of Action
Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking gastric acid production in the stomach
Route of Administration
Oral and intravenously (injection)
Dosages
For adults and children aged 12 years and older, the typical dosage is:
GERD: 40 mg once daily for up to 8 weeks
Renal Dose Adjustments
There are no specific renal dose adjustments recommended based on estimated glomerular filtration rate (eGFR) for pantoprazole; however, caution should be exercised in severe renal impairment.
Side Effects
| Frequency | Adverse reactions |
|---|---|
| Common Side Effects | |
| Diarrhea | |
| Abdominal pain | |
| Nausea | |
| Vomiting | |
| Flatulence | |
| Serious Side Effects | |
| Bone fractures | |
| Clostridium difficile infection | |
| Anaphylaxis | |
| Vitamin B12 deficiency |
Pharmacokinetics
Onset Time: Effects can be observed within 2 to 3 hours after oral administration.
Duration of Action: The acid-suppressive effect lasts approximately 24 hours.
Drug Precautions
Pregnancy: Pantoprazole should be used during pregnancy only if clearly needed, as its safety has not been established.
Breastfeeding: It is not known whether pantoprazole passes into breast milk; caution is advised.
Children and Elderly: Use in children over 5 years is generally safe; elderly patients may require monitoring due to the potential increased risk of side effects.
Monitoring Items
Regular monitoring of magnesium and vitamin B12 levels
Drug Interactions
Drug Interactions: Pantoprazole may interact with medications such as warfarin, methotrexate, and certain antifungals. It can affect the absorption of drugs that require an acidic environment.
FAQ
How should I take the tablet?
Take pantoprazole before meals, swallowing the tablet whole without crushing or chewing
What should I avoid while taking?
Avoid highly acidic foods and grapefruit
What happens if I miss a dose?
Take as soon as remembered unless close to next dose; do not double up on doses
